Epidemiology and clinical impact of Burkholderia cepacia complex: a single-centre analysis.

Julie Willekens, Hanneke Eyns, Elke De Wachter, Iris De Schutter, Annelies De Bel, F Echahidi, Anne Malfroot

Research output: Contribution to journalEditorial


Background: Burkholderia cepacia complex (Bcc), currently consisting of 17
species, is an important cause of morbidity and mortality in CF. B. cenocepacia
and B. multivorans are the most commonly isolated species.
Method: Medical files of all CF patients ever infected with Bcc in the period 1998-
2012 were reviewed. For each Bcc-infected patient, a control patient was matched
for age, gender and genotype.
Results: Over this 14 year-period, 18 patients were infected with Bcc: 10 were
chronically infected (8 B. multivorans, 1 B. vietnamensis, 1 B. stabilis) and 8 were
transiently infected. Prevalence of Bcc varied annually with a maximum of 4%.
Both groups, Bcc and control, had equal co-infection rates for Ps. aeruginosa (50
vs 40%, p = 0.34) and S. maltophilia (11 vs 22%, p = 0.37). However, in the group
chronically infected with Bcc, none had co-infection with S. maltophilia (vs 50%
in transient Bcc; pcontrol). Mean FEV1 1 and 2 years before and after acquisition was lower in Bcc
than controls, but statistically not significant. At time of Bcc acquisition, FEV1 was
significantly lower (pConclusion: Prevalence of Bcc in our centre is stable and low. Bcc infections are
predominantly caused by B. multivorans; B. cenocepacia infections did not occur.
Bcc infection was not associated with a faster clinical deterioration. Lower lung
function values at time of acquisition, suggest an association of Bcc acquisition
and pulmonary exacerbation.
Original languageEnglish
Pages (from-to)86-86
Number of pages1
JournalJournal of Cystic Fibrosis
Publication statusPublished - 2013


  • burkholderia cepacia


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