Epidemiology and clinicopathological characteristics of native kidney disease in children in Flanders, Belgium

FCGG collaborative group, Dries Deleersnijder, Noël Knops, Dominique Trouet, Koen Van Hoeck, Sevasti Karamaria, Johan Vande Walle, Reiner Mauel, Louise Cools, Gert Meeus, Amélie Dendooven, Johan De Meester, Wim Laurens, Ben Sprangers

Research output: Contribution to journalArticlepeer-review


Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is a population-based kidney biopsy registry that has been including all native kidney biopsies performed in children in Flanders (Belgium), since 2017. Methods: From 2017 to 2020, 148 pediatric (< 18 years) native kidney biopsies were included. Each biopsy received a histopathological and final nephrological diagnosis, and concordance between both was assessed. Disease chronicity, summarized by the Mayo Clinic Chronicity Score, was determined on 122 biopsies with > 5 glomeruli. Results: Kidney biopsy rate was high (29.0 biopsies per million children per year), median age was 10.0 years (IQR 5.8–14.7), and boys predominated (56.1% males). A total of 140 biopsies (94.6%) showed a representative pathology result. Glomerular disease was most prevalent, with IgA nephropathy/IgA vasculitis (43 biopsies, 29.1%) and minimal change disease (MCD) (29 biopsies, 19.6%) being the overall most frequent diagnoses. In general, diagnostic concordance was high (80.7%). In Alport syndrome and focal segmental glomerulosclerosis (FSGS), concordance was lower, as the nephrological diagnosis was often determined by results of genetic analysis. Nephrotic syndrome was the most frequent indication for kidney biopsy (31.8%) and was mainly caused by MCD and FSGS. The degree of disease chronicity on kidney biopsies was generally low, although 27.3% of biopsies with a diagnosis of FSGS showed moderate-to-severe chronic damage. Conclusions: The presented epidemiological findings validate data from previous European registry studies and may inspire kidney biopsy registries worldwide to implement novel features such as clinicopathological concordance and chronicity grading. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Article number36227435
Pages (from-to)1533-1545
Number of pages13
JournalPediatric Nephrology
Issue number5
Early online date13 Oct 2022
Publication statusPublished - May 2023

Bibliographical note

Funding Information:
Dries Deleersnijder is supported by a PhD Fellowship grant fundamental research from the Research Foundation Flanders (F.W.O., grant number 11L5622N). Ben Sprangers is a senior clinical investigator of The Research Foundation Flanders (F.W.O., grant number 1842919 N). The FCGG registry is funded by the Nederlandstalige Belgische Vereniging voor Nefrologie (NBVN).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to International Pediatric Nephrology Association.

Copyright 2023 Elsevier B.V., All rights reserved.


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