Establishing the Next-generation Multidimensional Liquid Chromatography

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract (Book)

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In spatial comprehensive three-dimensional chromatography (3D-LC) components are separated within a three-dimensional separation space that can lead to unprecedented resolving power, in terms of peak capacity and peak-production rate. The maximum peak capacity is the product of the peak capacities achieved in the individual dimensions when orthogonal retention mechanisms are incorporated. The parallel development of the second- and third-dimension separation stages overcomes the fundamental limitation of
conventional multi-dimensional approaches, in which sampled fractions are analyzed sequentially. General considerations for chip design are discussed and possibilities and prospects to establish spatial comprehensive 3D-LC analysis are presented.
Original languageEnglish
Title of host publication33rd International Symposium on Chromatography (ISC 2022) - Book of Abstracts
EditorsAttila Felinger
PublisherHungarian Society for Separation Sciences
Number of pages1
ISBN (Print)978-615-5270-74-1
Publication statusPublished - Sep 2022
Event33rd International Symposium on Chromatography – ISC 2022 - Budapest, Hungary
Duration: 18 Sep 202222 Sep 2022


Conference33rd International Symposium on Chromatography – ISC 2022


  • multi-dimensional liquid chromatography
  • microfluidic chips


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