European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis

J P Thyssen, C Vestergaard, M. Deleuran, M de Bruin-Weller, T. Bieber, Alain Taieb, J Seneschal, M Cork, C Flohr, Stephan Weidinger, M Trzeciak, T. Werfel, Annice Heratizadeh, S. Barbarot, U Darsow, D Simon, Antonio Torrelo, P Chernyshov, Jean-Francois Stadler, Carlo GelmettiZ Szalai, A. Svensson, L von Kobyletzki, Linda De Raeve, R Fölster-Holst, D Hijnen, Uwe Gieler, J. Ring, A. Wollenberg

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Surgery is a radical treatment for hidradenitis suppurativa (HS) and may be considered as the only one potentially curative. Objectives: To characterize HS recurrence in patients after surgery and assess the risk factors of recurrence. Methods: We conducted a monocentric retrospective cohort study. All consecutive patients who had surgery (January 1, 2012 to March 31, 2017) were included. We estimated the rate of recurrence of HS lesions after surgery (<1 cm from the scar), and recurrence-associated factors were analysed by univariate then multivariate logistic regression, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 75 patients [median age 31.4 years (range 16–71); 36 females], corresponding to 115 interventions were included. The Hurley score at surgery was III for 70 (60%) patients. In total, 61/115 (53%) interventions involved wide excision and 50 (43%) limited local excision. The localizations were axillary folds (n = 46; 40%), buttocks (n = 15, 13%), genital area (n = 13; 11%), perineal area (n = 12; 10%) and inguinal folds (n = 18; 16%). We observed 11 (10%) complications and 40 (35%) recurrences. On multivariate analysis, probability of recurrence was associated with only one-stage surgical closure [OR 3.2 (95% CI 1.4–7.3), P = 0.005]. Overall, 44 (52%) patients were completely satisfied and 22 (26%) partially satisfied, and most (81%) considered the surgery the best treatment. Conclusions: Hidradenitis suppurativa recurrence in our study was 35% and associated with one-stage surgical closures, but two-thirds of patients were satisfied with surgical treatment and would recommend surgery.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Volume34
Issue number4
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • atopic dermatitis
  • targets
  • EFTAD

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