TY - JOUR
T1 - Evaluation of appendicular lean mass using bio impedance in persons aged 80+
T2 - A new equation based on the BUTTERFLY-study
AU - Vermeiren, S
AU - Beckwée, D
AU - Vella-Azzopardi, R
AU - Beyer, I
AU - Knoop, V
AU - Jansen, B
AU - Delaere, A
AU - Antoine, A
AU - Bautmans, I
AU - Scafoglieri, A
AU - Gerontopole Brussels Study group
AU - Rossi, Gina
N1 - Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - BACKGROUND: To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear.OBJECTIVE: We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia.DESIGN: 174 community dwelling well-functioning persons (83 women, 91 men) aged 80 and over were included. Appendicular lean mass (ALM) was predicted using BIA-based equations available in literature, and compared to DXA outcomes. Through cross-validation and stepwise multiple linear regression, a new ALM-formula was generated suitable for this population.RESULTS: Literature-based BIA equations systematically overestimated ALM. The new prediction formula that we propose for the 80+ is: ALM = 0,827+(0,19*Impedance Index)+(2,101*Sex)+(0,079*Weight); R2 = 0,888; SEE = 1,450 kg. Sarcopenia classification based on our new BIA equation for ALM showed better agreement with DXA (k ≥ 0,454) compared to literature-based BIA equations (k < 0,368).CONCLUSIONS: Despite the high correlation between both methods, literature-based BIA equations consistently overestimate ALM compared to DXA in persons aged 80 and over. We proposed a new equation for ALM, reaching higher agreement with DXA and thus improving the accuracy of BIA for this specific age group.
AB - BACKGROUND: To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear.OBJECTIVE: We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia.DESIGN: 174 community dwelling well-functioning persons (83 women, 91 men) aged 80 and over were included. Appendicular lean mass (ALM) was predicted using BIA-based equations available in literature, and compared to DXA outcomes. Through cross-validation and stepwise multiple linear regression, a new ALM-formula was generated suitable for this population.RESULTS: Literature-based BIA equations systematically overestimated ALM. The new prediction formula that we propose for the 80+ is: ALM = 0,827+(0,19*Impedance Index)+(2,101*Sex)+(0,079*Weight); R2 = 0,888; SEE = 1,450 kg. Sarcopenia classification based on our new BIA equation for ALM showed better agreement with DXA (k ≥ 0,454) compared to literature-based BIA equations (k < 0,368).CONCLUSIONS: Despite the high correlation between both methods, literature-based BIA equations consistently overestimate ALM compared to DXA in persons aged 80 and over. We proposed a new equation for ALM, reaching higher agreement with DXA and thus improving the accuracy of BIA for this specific age group.
KW - Aged 80 and over
KW - Bioelectrical impedance analysis
KW - Body composition
KW - Dual X-ray absorptiometry
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85051507050&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2018.07.029
DO - 10.1016/j.clnu.2018.07.029
M3 - Article
C2 - 30119982
VL - 38
SP - 1756
EP - 1764
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 4
ER -