Projects per year
In this project, a chemical and toxicological screening is carried out to identify the potential migration risks related to the alternative materials. First, a market study was conducted to identify the various alternative materials. Next, representative samples were chosen and the migration experiments were performed according to EU Regulation 10/2011, followed by chemical identification of the migrants. In parallel, the toxicity (genotoxicity and endocrine activity) of the identified migrants was evaluated using a battery of in vitro assays. Afterwards, the exposure of the infants to the migrants was determined and the corresponding hazards were identified using relevant information from the database of the European Chemicals Agency (ECHA), in silico prediction tools (e.g. ToxTree) and the in vitro assays. Finally, a risk assessment of the identified substances was carried out. However, a distinction should be made between substances listed in Annex I of Regulation 10/2011 and the unlisted substances (e.g. Non Intentionally Added Substances (NIAS)). While the concentration of the listed substances in the migration solutions were compared to their respective specific migration limits (when applicable), the exposure of the unlisted substances was compared to the thresholds determined by the Threshold of Toxicological Concern (TTC) concept. The results have shown that the concentrations of all listed substances were always below their specific migration limits. However, the exposure of some unlisted substances frequently exceeded the human exposure threshold determined by the TTC-concept. An in-depth risk assessment of these substances needs to be performed.
Finally, it can be concluded that the safety evaluation of baby bottles is challenging due to insufficient analytical data for the identification of NIAS and authorized components. Furthermore, there is also an urgent need in more (public available) toxicological information and exposure data for risk assessment.
|Publication status||Published - 18 Nov 2016|
|Event||ILSI Europe's 6th International Symposium on Food Packaging: Scientific Developments Supporting Safety and Innovation - Crowne Plaza Barcelona - Fira Center, Barcelona, Spain|
Duration: 16 Nov 2016 → 18 Nov 2016
|Conference||ILSI Europe's 6th International Symposium on Food Packaging|
|Abbreviated title||ILSI 2016|
|Period||16/11/16 → 18/11/16|
- Food Safety
- Polycarbonate replacement products
FingerprintDive into the research topics of 'Evaluation of the potential migration risks of baby bottles used as substitutes for polycarbonate - Poster @ ILSI Europe 2016: Poster S1-63-B'. Together they form a unique fingerprint.
FVO46: Studie van de eventuele migratierisico's van materialen die in contact komen met levensmiddelen voor kinderen jonger dan 3 jaar (ALTPOLYCARB)
1/11/12 → 31/10/15
Investigation of the Genotoxicity of Substances Migrating From Polycarbonate Replacement Baby Bottles to Identify Chemicals of High Concern - Poster @ ILSI Europe 2016: Poster S1-39-BMertens, B., Simon, C., Van Bossuyt, M., Onghena, M., Vandermarken, T., Van Langenhove, K., Demaegdt, H., Van Hoeck, E., Van Loco, J., Vandermeiren, K., Covaci, A., Scippo, M-L., Elskens, M. & Verschaeve, L., 18 Nov 2016.
Research output: Unpublished contribution to conference › Poster
Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassaysSimon, C., Onghena, M., Covaci, A., Van Hoeck, E., Van Loco, J., Vandermarken, T., Van Langenhove, K., Demaegdt, H., Mertens, B., Vandermeiren, K., Scippo, M. & Elskens, M., 17 Oct 2016, In: Toxicology in Vitro. 37, p. 121-133 13 p.
Research output: Contribution to journal › Article › peer-review20 Citations (Scopus)
Marc Elskens (Manager)Analytical, Environmental & Geo-Chemistry