TY - JOUR
T1 - Extracytoplasmic function sigma factors in Pseudomonas aeruginosa
AU - Chevalier, Sylvie
AU - Bouffartigues, Emeline
AU - Bazire, Alexis
AU - Tahrioui, Ali
AU - Duchesne, Rachel
AU - Tortuel, Damien
AU - Maillot, Olivier
AU - Clamens, Thomas
AU - Orange, Nicole
AU - Feuilloley, Marc G J
AU - Lesouhaitier, Olivier
AU - Dufour, Alain
AU - Cornelis, Pierre
N1 - Copyright © 2018. Published by Elsevier B.V.
PY - 2019/7
Y1 - 2019/7
N2 - The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus Pseudomonas, has the capacity to thrive in very different environments, ranging from water, plant roots, to animals, including humans to whom it can cause severe infections. This remarkable adaptability is reflected in the number of transcriptional regulators, including sigma factors in this bacterium. Among those, the 19 to 21 extracytoplasmic sigma factors (ECFσ) are endowed with different regulons and functions, including the iron starvation σ (PvdS, FpvI, HasI, FecI, FecI2 and others), the cell wall stress ECFσ AlgU, SigX and SbrI, and the unorthodox σVreI involved in the expression of virulence. Recently published data show that these ECFσ have separate regulons although presenting some cross-talk. We will present evidence that these different ECFσ are involved in the expression of different phenotypes, ranging from cell-wall stress response, production of extracellular polysaccharides, formation of biofilms, to iron acquisition.
AB - The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus Pseudomonas, has the capacity to thrive in very different environments, ranging from water, plant roots, to animals, including humans to whom it can cause severe infections. This remarkable adaptability is reflected in the number of transcriptional regulators, including sigma factors in this bacterium. Among those, the 19 to 21 extracytoplasmic sigma factors (ECFσ) are endowed with different regulons and functions, including the iron starvation σ (PvdS, FpvI, HasI, FecI, FecI2 and others), the cell wall stress ECFσ AlgU, SigX and SbrI, and the unorthodox σVreI involved in the expression of virulence. Recently published data show that these ECFσ have separate regulons although presenting some cross-talk. We will present evidence that these different ECFσ are involved in the expression of different phenotypes, ranging from cell-wall stress response, production of extracellular polysaccharides, formation of biofilms, to iron acquisition.
KW - Biofilm formation
KW - Cell wall stress response
KW - ECFσ
KW - Iron uptake
KW - Pseudomonas aeruginosa
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=85046699412&partnerID=8YFLogxK
U2 - 10.1016/j.bbagrm.2018.04.008
DO - 10.1016/j.bbagrm.2018.04.008
M3 - Scientific review
C2 - 29729420
VL - 1862
SP - 706
EP - 721
JO - Biochimica et Biophysica Acta Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta Gene Regulatory Mechanisms
SN - 1874-9399
IS - 7
ER -