Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine

L Gucciardo, R Lories, N Ochsenbein-Kölble, E Done', A Zwijsen, J Deprest

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The fetus is a source of nonembryonic stem cells (SC), with potential applications in perinatal medicine. Cells derived from the placenta, membranes, amniotic fluid or fetal tissues are higher in number, expansion potential and differentiation abilities compared with SC from adult tissues. Although some obstacles keep SC biology at distance from clinical application, the feasibility of using (homologous) SC for tissue engineering for the fetus with a congenital birth defect has been demonstrated. Also, other pathologies may benefit from SC technology.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalBritish Journal of Obstetrics and Gynaecology
Volume116
Issue number2
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Adult
  • Female
  • Fetal Stem Cells
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stromal Cells
  • Perinatology
  • Pregnancy
  • Regenerative Medicine
  • Tissue and Organ Harvesting

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