Fluid Management in Sepsis

Research output: Chapter in Book/Report/Conference proceedingChapter


Adequate fluid management in sepsis requires a thoughtful approach. While early aggressive fluid therapy is generally required, one should also be aware of the risks of blind continued administration of large fluid volumes. In the first part of this chapter, we offer an in-depth literature overview on the available fluids in sepsis. In the second part, we stress the importance and prove the relevance of viewing fluids as drugs. Finally, we explain that sepsis can be divided into four temporally distinct phases each requiring a different fluid strategy: resuscitation, optimization, stabilization, and evacuation. We offer a phase-by-phase guidance using this ROSE conceptual model.
Original languageEnglish
Title of host publicationTransfusion Practice in Clinical Neurosciences
Number of pages13
ISBN (Electronic)978-981-19-0954-2
ISBN (Print)978-981-19-0953-5
Publication statusPublished - 18 Jun 2022

Bibliographical note

Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.

Copyright 2023 Elsevier B.V., All rights reserved.


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