Fluorescent visualization of the mitochondrial membrane potential gradient identifies oxidative phosphorylation defects in fibroblasts.

Rudy Van Coster; Boél De Paepe; Joél Smet; Sara Seneca; Willy Lissens; Linda De Meirleir; R. Rodenburg

Fluorescent visualization of the mitochondrial membrane potential gradient identifies oxidative phosphorylation defects in fibroblasts.

Rudy Van Coster, Boél De Paepe, Joél Smet, Sara Seneca, Willy Lissens, Linda De Meirleir, R. Rodenburg

Department of Embryology and Genetics

Research output: Contribution to journal › Conference paper

205 Citations (Scopus)

Abstract

We found that JC-1 fluorescent microscopy allows to detect and differentiate OXPHOS defects and thus may be employed to study fibroblasts from suspected patients.

Original language	English
Pages (from-to)	159-159
Number of pages	1
Journal	Journal of Inherited Metabolic Disease
Volume	34
Publication status	Published - Aug 2011

Keywords

OXPHOS defects
ATP synthase
JC-1 fluorescent microscopy

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@article{c6177bb9c03a42d49760d300613b3960,

title = "Fluorescent visualization of the mitochondrial membrane potential gradient identifies oxidative phosphorylation defects in fibroblasts.",

abstract = "We found that JC-1 fluorescent microscopy allows to detect and differentiate OXPHOS defects and thus may be employed to study fibroblasts from suspected patients.",

keywords = "OXPHOS defects, ATP synthase, JC-1 fluorescent microscopy",

author = "{Van Coster}, Rudy and {De Paepe}, Bo{\'e}l and Jo{\'e}l Smet and Sara Seneca and Willy Lissens and {De Meirleir}, Linda and R. Rodenburg",

year = "2011",

month = aug,

language = "English",

volume = "34",

pages = "159--159",

journal = "Journal of Inherited Metabolic Disease",

issn = "0141-8955",

publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Fluorescent visualization of the mitochondrial membrane potential gradient identifies oxidative phosphorylation defects in fibroblasts.

AU - Van Coster, Rudy

AU - De Paepe, Boél

AU - Smet, Joél

AU - Seneca, Sara

AU - Lissens, Willy

AU - De Meirleir, Linda

AU - Rodenburg, R.

PY - 2011/8

Y1 - 2011/8

N2 - We found that JC-1 fluorescent microscopy allows to detect and differentiate OXPHOS defects and thus may be employed to study fibroblasts from suspected patients.

AB - We found that JC-1 fluorescent microscopy allows to detect and differentiate OXPHOS defects and thus may be employed to study fibroblasts from suspected patients.

KW - OXPHOS defects

KW - ATP synthase

KW - JC-1 fluorescent microscopy

M3 - Conference paper

SN - 0141-8955

VL - 34

SP - 159

EP - 159

JO - Journal of Inherited Metabolic Disease

JF - Journal of Inherited Metabolic Disease

ER -

Fluorescent visualization of the mitochondrial membrane potential gradient identifies oxidative phosphorylation defects in fibroblasts.

Abstract

Keywords

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