TY - GEN
T1 - Functional performance recovery after individualized nutrition therapy combined with a patient-tailored physical rehabilitation program versus standard physiotherapy in patients with long COVID: a pilot study
AU - Roggeman, Stijn Jozef
AU - Jimenez Garcia, Berenice Gabriela
AU - Leemans, Lynn
AU - Demol, Joy
AU - Geers, Janne
AU - De Smedt, Ann
AU - Putman, Koen
AU - Schiltz, Marc
AU - Beckwée, David
AU - De Waele, Elisabeth
N1 - Funding Information:
This work was supported by the Belgian Health Care Knowledge Centre, as part of their KCE Trials program, trial number LCOV-21–1306.
Publisher Copyright:
© 2023, BioMed Central Ltd., part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Background: Long COVID is suggested to be present in 14 to 43% of COVID 19-survivors. Literature on this new condition states a need for a multidisciplinary approach including physical exercise and nutrition. The aim of the current pilot study is to investigate the feasibility of the proposed protocol to prepare for a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment compared to standard physiotherapy. Methods: This is a protocol of the UNLOCK (Nutrition and LOComotoric rehabilitation in long COVID) study, a pragmatic, single center, randomized controlled pilot trial with two groups. Patients with persisting symptoms related to a SARS-CoV-2 infection will receive either standard physiotherapy or a personalized multimodal treatment for a period of 12 weeks, consisting of individualized physical exercise program combined with individualized nutritional therapy. They will be followed-up at 6, 12, and 18 weeks after randomization. Discussion: A multidisciplinary approach for dealing with long COVID is needed. Because of the lack of clear data and the fact that this is a very heterogenic group, we aim to prepare and optimize a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment. Trial registration: ClinicalTrials.gov Identifier: NCT05254301 (since February 24, 2022).
AB - Background: Long COVID is suggested to be present in 14 to 43% of COVID 19-survivors. Literature on this new condition states a need for a multidisciplinary approach including physical exercise and nutrition. The aim of the current pilot study is to investigate the feasibility of the proposed protocol to prepare for a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment compared to standard physiotherapy. Methods: This is a protocol of the UNLOCK (Nutrition and LOComotoric rehabilitation in long COVID) study, a pragmatic, single center, randomized controlled pilot trial with two groups. Patients with persisting symptoms related to a SARS-CoV-2 infection will receive either standard physiotherapy or a personalized multimodal treatment for a period of 12 weeks, consisting of individualized physical exercise program combined with individualized nutritional therapy. They will be followed-up at 6, 12, and 18 weeks after randomization. Discussion: A multidisciplinary approach for dealing with long COVID is needed. Because of the lack of clear data and the fact that this is a very heterogenic group, we aim to prepare and optimize a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment. Trial registration: ClinicalTrials.gov Identifier: NCT05254301 (since February 24, 2022).
UR - http://www.scopus.com/inward/record.url?scp=85173094233&partnerID=8YFLogxK
U2 - 10.1186/s40814-023-01392-1
DO - 10.1186/s40814-023-01392-1
M3 - Article
C2 - 37759324
VL - 9
JO - Pilot and feasibility studies
JF - Pilot and feasibility studies
SN - 2055-5784
ER -