Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination.

M Hasso-Agopsowicz, CN Ladva, B Lopman, C Sanderson, AL Cohen, X Riveros, AM Henao-Restrepo, A Clark, Global Rotavirus Surveillance Network and Rotavirus Age Study Collaborators, Tessa Braeckman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.

Original languageEnglish
Pages (from-to)1071-1078
Number of pages8
JournalClinical Infectious Diseases
Volume69
Issue number6
DOIs
Publication statusPublished - 30 Aug 2019

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