Abstract
Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be implemented in cancer diagnosis, monitoring, and therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 392-394 |
| Number of pages | 3 |
| Journal | Trends in cancer |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2021 |
| Externally published | Yes |
Bibliographical note
Funding Information:Research by JI and KODB in the lab of Professor Guy Van Camp is supported by research grants awarded by the University of Antwerp ( BOF/Methusalem grant 40790 , IOF/SBO 43782 , BOF/TOP 39705 ). JI is supported by a PhD fellowship of the Research Foundation – Flanders (FWO; 11B5220N ). Research by ED in the unit of Professor Peter Vandenabeele was supported by EOS MODEL-IDI , FWO research grants ( G.0E04.16N , G.0C76.18N , G.0B71.18N , G.0B96.20N ), Methusalem ( BOF16/MET_V/007 ), Foundation against Cancer ( F/2016/865 , F/2020/1505 ), CRIG and GIGG consortia, and VIB. The authors acknowledge Professor Guy Van Camp for critically reading the manuscript and contributing to its final form.
Publisher Copyright:
© 2020 Elsevier Inc.
Keywords
- Antineoplastic Agents/pharmacology
- Biomarkers, Tumor/agonists
- Cell Line, Tumor
- DNA Methylation
- Early Detection of Cancer/methods
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Humans
- Loss of Function Mutation
- Molecular Targeted Therapy/methods
- Neoplasms/diagnosis
- Prognosis
- Promoter Regions, Genetic/genetics
- Pyroptosis/drug effects
- Receptors, Estrogen/genetics
- Risk Assessment/methods