Harnessing Beta Cell Regeneration Biology for Diabetes Therapy

Stephanie Bourgeois; Sophie Coenen; Laure Degroote; Lien Willems; Annelore Van Mulders; Julie Annie Pierreux; Yves Heremans; Nico De Leu; Willem Staels

doi:10.1016/j.tem.2024.03.006

Harnessing Beta Cell Regeneration Biology for Diabetes Therapy

Stephanie Bourgeois, Sophie Coenen, Laure Degroote, Lien Willems, Annelore Van Mulders, Julie Annie Pierreux, Yves Heremans, Nico De Leu, Willem Staels

Research output: Contribution to journal › Scientific review › peer-review

1 Citation (Scopus)

Abstract

The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from ‘caring for’ to ‘curing’ diabetes.

Original language	English
Pages (from-to)	951-966
Number of pages <span style="color:red"p> <font size="1.5"> ✽ </span> </font>	16
Journal	Trends in Endocrinology and Metabolism
Volume	35
Issue number	11
DOIs	https://doi.org/10.1016/j.tem.2024.03.006
Publication status	Published - Nov 2024

Bibliographical note

Funding Information:
This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) (G040719N, G099323N, G058122N, 1806421N), Diabetes Onderzoek Nederland (DON), and JDRF (2-SRA-2022-1200-S-B, 5-CDA-2024-1491-S-B). S.B. S.C. and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations. S.B. S.C. L.D. and L.W. wrote the manuscript with support from J.P. and A.V.M. Y.H. edited and reviewed the manuscript. N.D.L. and W.S. conceptualized the topic and supervised writing. The authors have no interests to declare.

Funding Information:
This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) ( G099323N , G058122N , 1806421N ), Diabetes Onderzoek Nederland (DON), and JDRF ( 2-SRA-2022-1200-S-B , 5-CDA-2024-1491-S-B ). S.B., S.C., and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations.

Publisher Copyright:
© 2024 The Authors

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10.1016/j.tem.2024.03.006

Cite this

@article{e431d55b75f647979b7e0446e4c24760,

title = "Harnessing Beta Cell Regeneration Biology for Diabetes Therapy",

abstract = "The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from {\textquoteleft}caring for{\textquoteright} to {\textquoteleft}curing{\textquoteright} diabetes.",

author = "Stephanie Bourgeois and Sophie Coenen and Laure Degroote and Lien Willems and {Van Mulders}, Annelore and Pierreux, {Julie Annie} and Yves Heremans and {De Leu}, Nico and Willem Staels",

note = "Funding Information: This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) (G040719N, G099323N, G058122N, 1806421N), Diabetes Onderzoek Nederland (DON), and JDRF (2-SRA-2022-1200-S-B, 5-CDA-2024-1491-S-B). S.B. S.C. and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations. S.B. S.C. L.D. and L.W. wrote the manuscript with support from J.P. and A.V.M. Y.H. edited and reviewed the manuscript. N.D.L. and W.S. conceptualized the topic and supervised writing. The authors have no interests to declare. Funding Information: This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) ( G099323N , G058122N , 1806421N ), Diabetes Onderzoek Nederland (DON), and JDRF ( 2-SRA-2022-1200-S-B , 5-CDA-2024-1491-S-B ). S.B., S.C., and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations. Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = nov,

doi = "10.1016/j.tem.2024.03.006",

language = "English",

volume = "35",

pages = "951--966",

journal = "Trends in Endocrinology and Metabolism",

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}

Harnessing Beta Cell Regeneration Biology for Diabetes Therapy. / Bourgeois, Stephanie ; Coenen, Sophie ; Degroote, Laure ; Willems, Lien ; Van Mulders, Annelore ; Pierreux, Julie Annie ; Heremans, Yves ; De Leu, Nico ; Staels, Willem.

In: Trends in Endocrinology and Metabolism, Vol. 35, No. 11, 11.2024, p. 951-966.

Research output: Contribution to journal › Scientific review › peer-review

TY - JOUR

T1 - Harnessing Beta Cell Regeneration Biology for Diabetes Therapy

AU - Bourgeois, Stephanie

AU - Coenen, Sophie

AU - Degroote, Laure

AU - Willems, Lien

AU - Van Mulders, Annelore

AU - Pierreux, Julie Annie

AU - Heremans, Yves

AU - De Leu, Nico

AU - Staels, Willem

N1 - Funding Information: This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) (G040719N, G099323N, G058122N, 1806421N), Diabetes Onderzoek Nederland (DON), and JDRF (2-SRA-2022-1200-S-B, 5-CDA-2024-1491-S-B). S.B. S.C. and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations. S.B. S.C. L.D. and L.W. wrote the manuscript with support from J.P. and A.V.M. Y.H. edited and reviewed the manuscript. N.D.L. and W.S. conceptualized the topic and supervised writing. The authors have no interests to declare. Funding Information: This work was supported by grants from the Research Foundation \u2013 Flanders (FWO) ( G099323N , G058122N , 1806421N ), Diabetes Onderzoek Nederland (DON), and JDRF ( 2-SRA-2022-1200-S-B , 5-CDA-2024-1491-S-B ). S.B., S.C., and A.V.M. are doctoral fellows from the FWO with grant numbers 1S89821N, 11P3Z24N, and 11I3123N, respectively. We apologize to colleagues whose work could not be included due to space limitations. Publisher Copyright: © 2024 The Authors

PY - 2024/11

Y1 - 2024/11

N2 - The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from ‘caring for’ to ‘curing’ diabetes.

AB - The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from ‘caring for’ to ‘curing’ diabetes.

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U2 - 10.1016/j.tem.2024.03.006

DO - 10.1016/j.tem.2024.03.006

M3 - Scientific review

VL - 35

SP - 951

EP - 966

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 11

ER -

Harnessing Beta Cell Regeneration Biology for Diabetes Therapy

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