TY - JOUR
T1 - Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
AU - Mekeirele, Michaël Maurits M
AU - Verheyen, Silke
AU - Van Lancker, Ruth
AU - Wuyts, Stephanie
AU - Balthazar, Tim
N1 - Publisher Copyright:
© 2022
Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.
PY - 2022/9/26
Y1 - 2022/9/26
N2 - Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.
AB - Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.
UR - http://www.scopus.com/inward/record.url?scp=85141289385&partnerID=8YFLogxK
U2 - 10.1159/000526323
DO - 10.1159/000526323
M3 - Article
C2 - 36518360
SN - 2296-9705
VL - 12
SP - 163
EP - 166
JO - Case Reports in Nephrology and Dialysis
JF - Case Reports in Nephrology and Dialysis
IS - 3
ER -