Hepatic cell junctions: pulling a double-duty

Raf Van Campenhout; Mathieu Vinken

doi:10.1111/liv.16045

Hepatic cell junctions: pulling a double-duty

Raf Van Campenhout, Mathieu Vinken

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

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Abstract

Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

Original language	English
Pages (from-to)	2873-2889
Number of pages	17
Journal	Liver International
Volume	44
Issue number	11
DOIs	https://doi.org/10.1111/liv.16045
Publication status	Published - Nov 2024

Bibliographical note

Funding Information:
This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts).

Funding Information:
This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders\u2010Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel\u2010Belgium (Scientific Fund Willy Gepts).

Publisher Copyright:
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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10.1111/liv.16045Licence: Unspecified

112968104Accepted author manuscript, 790 KBLicence: Unspecified

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title = "Hepatic cell junctions: pulling a double-duty",

abstract = "Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.",

author = "{Van Campenhout}, Raf and Mathieu Vinken",

note = "Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts). Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders\u2010Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel\u2010Belgium (Scientific Fund Willy Gepts). Publisher Copyright: {\textcopyright} 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2024",

month = nov,

doi = "10.1111/liv.16045",

language = "English",

volume = "44",

pages = "2873--2889",

journal = "Liver International",

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AU - Van Campenhout, Raf

AU - Vinken, Mathieu

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N2 - Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

AB - Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

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U2 - 10.1111/liv.16045

DO - 10.1111/liv.16045

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SN - 1478-3223

VL - 44

SP - 2873

EP - 2889

JO - Liver International

JF - Liver International

IS - 11

ER -

Hepatic cell junctions: pulling a double-duty

Abstract

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FWOAL1070: The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance.

OZRMETH6: Cellular communication as target and biomarker in liver disease and toxicity: from basic research towards clinical application

EU624: Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular and hepatic diseases

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Hepatic cell junctions: pulling a double-duty

Abstract

Bibliographical note

Access to Document

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Other files and links

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Projects

FWOAL1070: The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance.

OZRMETH6: Cellular communication as target and biomarker in liver disease and toxicity: from basic research towards clinical application

EU624: Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular and hepatic diseases

Cite this