Heterogeneity and function of macrophages in the breast during homeostasis and cancer

Eva Hadadi, Sofie Deschoemaeker, Gerard Vicente Venegas, Damya Laoui

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.
Original languageEnglish
Title of host publicationPaOne, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease
PublisherElsevier
Pages149-182
ISBN (Electronic)978-0-323-90741-5
DOIs
Publication statusPublished - 2022

Publication series

NameInternational Review of Cell and Molecular Biology
ISSN (Print)0074-7696

Keywords

  • MacrophagesBreast cancerTumor-associated macrophagesMammary glandHypoxia

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