Heterogeneity and function of macrophages in the breast during homeostasis and cancer

Eva Hadadi, Sofie Deschoemaeker, Gerard Vicente Venegas, Damya Laoui

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.
Original languageEnglish
Title of host publicationOne, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A
EditorsSamanta A. Mariani, Luca Cassetta, Lorenzo Galluzzi
PublisherElsevier
Pages149-182
Number of pages34
ISBN (Electronic)978-0-323-90741-5
ISBN (Print)9780323907415
DOIs
Publication statusPublished - Jan 2022

Publication series

NameInternational Review of Cell and Molecular Biology
Volume367
ISSN (Print)1937-6448

Bibliographical note

Funding Information:
E.H. is supported by an FWO postdoctoral fellowship, S.D. is supported by a postdoctoral fellowship from Stichting tegen kanker , D.L. is supported by grants from FWO, Kom op Tegen Kanker , Stichting tegen kanker and Vrije Universiteit Brussel .

Publisher Copyright:
© 2022 Elsevier Inc.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Keywords

  • MacrophagesBreast cancerTumor-associated macrophagesMammary glandHypoxia

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