Heterogeneity and function of macrophages in the breast during homeostasis and cancer

Eva Hadadi; Sofie Deschoemaeker; Gerard Vicente Venegas; Damya Laoui

doi:10.1016/bs.ircmb.2022.01.002

Heterogeneity and function of macrophages in the breast during homeostasis and cancer

Eva Hadadi, Sofie Deschoemaeker, Gerard Vicente Venegas, Damya Laoui

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

3 Citations (Scopus)

Abstract

Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.

Original language	English
Title of host publication	One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A
Editors	Samanta A. Mariani, Luca Cassetta, Lorenzo Galluzzi
Publisher	Elsevier
Pages	149-182
Number of pages	34
ISBN (Electronic)	978-0-323-90741-5
ISBN (Print)	9780323907415
DOIs	https://doi.org/10.1016/bs.ircmb.2022.01.002
Publication status	Published - Jan 2022

Publication series

Name	International Review of Cell and Molecular Biology
Volume	367
ISSN (Print)	1937-6448

Bibliographical note

Funding Information:
E.H. is supported by an FWO postdoctoral fellowship, S.D. is supported by a postdoctoral fellowship from Stichting tegen kanker , D.L. is supported by grants from FWO, Kom op Tegen Kanker , Stichting tegen kanker and Vrije Universiteit Brussel .

Publisher Copyright:
© 2022 Elsevier Inc.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Keywords

MacrophagesBreast cancerTumor-associated macrophagesMammary glandHypoxia

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Hadadi, E., Deschoemaeker, S., Vicente Venegas, G., & Laoui, D. (2022). Heterogeneity and function of macrophages in the breast during homeostasis and cancer. In S. A. Mariani, L. Cassetta, & L. Galluzzi (Eds.), One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A (pp. 149-182). (International Review of Cell and Molecular Biology; Vol. 367). Elsevier. https://doi.org/10.1016/bs.ircmb.2022.01.002

Hadadi, Eva ; Deschoemaeker, Sofie ; Vicente Venegas, Gerard et al. / Heterogeneity and function of macrophages in the breast during homeostasis and cancer. One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A. editor / Samanta A. Mariani ; Luca Cassetta ; Lorenzo Galluzzi. Elsevier, 2022. pp. 149-182 (International Review of Cell and Molecular Biology).

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abstract = "Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.",

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author = "Eva Hadadi and Sofie Deschoemaeker and {Vicente Venegas}, Gerard and Damya Laoui",

note = "Funding Information: E.H. is supported by an FWO postdoctoral fellowship, S.D. is supported by a postdoctoral fellowship from Stichting tegen kanker , D.L. is supported by grants from FWO, Kom op Tegen Kanker , Stichting tegen kanker and Vrije Universiteit Brussel . Publisher Copyright: {\textcopyright} 2022 Elsevier Inc. Copyright: Copyright 2023 Elsevier B.V., All rights reserved.",

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Hadadi, E , Deschoemaeker, S, Vicente Venegas, G & Laoui, D 2022, Heterogeneity and function of macrophages in the breast during homeostasis and cancer. in SA Mariani, L Cassetta & L Galluzzi (eds), One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A. International Review of Cell and Molecular Biology, vol. 367, Elsevier, pp. 149-182. https://doi.org/10.1016/bs.ircmb.2022.01.002

Heterogeneity and function of macrophages in the breast during homeostasis and cancer. / Hadadi, Eva ; Deschoemaeker, Sofie; Vicente Venegas, Gerard et al.
One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A. ed. / Samanta A. Mariani; Luca Cassetta; Lorenzo Galluzzi. Elsevier, 2022. p. 149-182 (International Review of Cell and Molecular Biology; Vol. 367).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

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T1 - Heterogeneity and function of macrophages in the breast during homeostasis and cancer

AU - Hadadi, Eva

AU - Deschoemaeker, Sofie

AU - Vicente Venegas, Gerard

AU - Laoui, Damya

N1 - Funding Information: E.H. is supported by an FWO postdoctoral fellowship, S.D. is supported by a postdoctoral fellowship from Stichting tegen kanker , D.L. is supported by grants from FWO, Kom op Tegen Kanker , Stichting tegen kanker and Vrije Universiteit Brussel . Publisher Copyright: © 2022 Elsevier Inc. Copyright: Copyright 2023 Elsevier B.V., All rights reserved.

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N2 - Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.

AB - Macrophages are diverse immune cells populating all tissues and adopting a unique tissue-specific identity. Breast macrophages play an essential role in the development and function of the mammary gland over one's lifetime. In the recent years, with the development of fate-mapping, imaging and scRNA-seq technologies we grew a better understanding of the origin, heterogeneity and function of mammary macrophages in homeostasis but also during breast cancer development. Here, we aim to provide a comprehensive review of the latest improvements in studying the macrophage heterogeneity in healthy mammary tissues and breast cancer.

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SP - 149

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BT - One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A

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Hadadi E , Deschoemaeker S, Vicente Venegas G, Laoui D. Heterogeneity and function of macrophages in the breast during homeostasis and cancer. In Mariani SA, Cassetta L, Galluzzi L, editors, One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A. Elsevier. 2022. p. 149-182. (International Review of Cell and Molecular Biology). doi: 10.1016/bs.ircmb.2022.01.002

Heterogeneity and function of macrophages in the breast during homeostasis and cancer

Abstract

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Keywords

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