Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2

INTERACT Investigators; Shoichiro Sato; E Heeley; H Arima; Candice Delcourt; Yoichiro Hirakawa; Vijaya Pamidimukkala; Zhendong Li; Qingling Tao; Yuehong Xu; Michael G Hennerici; Thompson Robinson; Christophe Tzourio; Richard I Lindley; J Chalmers; C S Anderson; C S Anderson; Y Huang; J G Wang; H Arima; B Neal; B Peng; E Heeley; C Skulina; M W Parsons; J S Kim; Q L Tao; Y C Li; J D Jiang; L W Tai; L J Zhang; E Xu; Y Cheng; S Heritier; L B Morgenstern; J Chalmers

doi:10.1136/jnnp-2014-309870

Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2

INTERACT Investigators, Shoichiro Sato, E Heeley, H Arima, Candice Delcourt, Yoichiro Hirakawa, Vijaya Pamidimukkala, Zhendong Li, Qingling Tao, Yuehong Xu, Michael G Hennerici, Thompson Robinson, Christophe Tzourio, Richard I Lindley, J Chalmers, C S Anderson, C S Anderson, Y Huang, J G Wang, H ArimaB Neal, B Peng, E Heeley, C Skulina, M W Parsons, J S Kim, Q L Tao, Y C Li, J D Jiang, L W Tai, L J Zhang, E Xu, Y Cheng, S Heritier, L B Morgenstern, J Chalmers

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.

METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.

RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).

CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.

TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

Original language	English
Pages (from-to)	1319-1323
Number of pages	5
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	86
Issue number	12
DOIs	https://doi.org/10.1136/jnnp-2014-309870
Publication status	Published - Dec 2015

Bibliographical note

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Keywords

Aged
Blood Pressure/drug effects
Cause of Death
Cerebral Hemorrhage/mortality
Disability Evaluation
Endpoint Determination
Female
Functional Laterality
Glasgow Coma Scale
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pilot Projects
Prognosis
Survivors
Treatment Outcome

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10.1136/jnnp-2014-309870

Cite this

INTERACT Investigators, Sato, S., Heeley, E., Arima, H., Delcourt, C., Hirakawa, Y., Pamidimukkala, V., Li, Z., Tao, Q., Xu, Y., Hennerici, M. G., Robinson, T., Tzourio, C., Lindley, R. I., Chalmers, J., Anderson, C. S., Anderson, C. S., Huang, Y., Wang, J. G., ... Chalmers, J. (2015). Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2. Journal of Neurology, Neurosurgery and Psychiatry, 86(12), 1319-1323. https://doi.org/10.1136/jnnp-2014-309870

INTERACT Investigators ; Sato, Shoichiro ; Heeley, E ; Arima, H ; Delcourt, Candice ; Hirakawa, Yoichiro ; Pamidimukkala, Vijaya ; Li, Zhendong ; Tao, Qingling ; Xu, Yuehong ; Hennerici, Michael G ; Robinson, Thompson ; Tzourio, Christophe ; Lindley, Richard I ; Chalmers, J ; Anderson, C S ; Anderson, C S ; Huang, Y ; Wang, J G ; Arima, H ; Neal, B ; Peng, B ; Heeley, E ; Skulina, C ; Parsons, M W ; Kim, J S ; Tao, Q L ; Li, Y C ; Jiang, J D ; Tai, L W ; Zhang, L J ; Xu, E ; Cheng, Y ; Heritier, S ; Morgenstern, L B ; Chalmers, J. / Higher mortality in patients with right hemispheric intracerebral haemorrhage : INTERACT1 and 2. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 12. pp. 1319-1323.

@article{965ce8a41a84449291fa859b1d67454d,

title = "Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2",

abstract = "BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.",

keywords = "Aged, Blood Pressure/drug effects, Cause of Death, Cerebral Hemorrhage/mortality, Disability Evaluation, Endpoint Determination, Female, Functional Laterality, Glasgow Coma Scale, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pilot Projects, Prognosis, Survivors, Treatment Outcome",

author = "{INTERACT Investigators} and Shoichiro Sato and E Heeley and H Arima and Candice Delcourt and Yoichiro Hirakawa and Vijaya Pamidimukkala and Zhendong Li and Qingling Tao and Yuehong Xu and Hennerici, {Michael G} and Thompson Robinson and Christophe Tzourio and Lindley, {Richard I} and J Chalmers and Anderson, {C S} and Anderson, {C S} and Y Huang and Wang, {J G} and H Arima and B Neal and B Peng and E Heeley and C Skulina and Parsons, {M W} and Kim, {J S} and Tao, {Q L} and Li, {Y C} and Jiang, {J D} and Tai, {L W} and Zhang, {L J} and E Xu and Y Cheng and S Heritier and Morgenstern, {L B} and J Chalmers and {De Raedt}, Sylvie and Raf Brouns and {De Smedt}, Ann and {De Keyser}, Jacques and {Van Hooff}, {Robbert-Jan Roderick}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",

year = "2015",

month = dec,

doi = "10.1136/jnnp-2014-309870",

language = "English",

volume = "86",

pages = "1319--1323",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ Publishing Group",

number = "12",

}

INTERACT Investigators, Sato, S, Heeley, E, Arima, H, Delcourt, C, Hirakawa, Y, Pamidimukkala, V, Li, Z, Tao, Q, Xu, Y, Hennerici, MG, Robinson, T, Tzourio, C, Lindley, RI, Chalmers, J, Anderson, CS, Anderson, CS, Huang, Y, Wang, JG, Arima, H, Neal, B, Peng, B, Heeley, E, Skulina, C, Parsons, MW, Kim, JS, Tao, QL, Li, YC, Jiang, JD, Tai, LW, Zhang, LJ, Xu, E, Cheng, Y, Heritier, S, Morgenstern, LB & Chalmers, J 2015, 'Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 12, pp. 1319-1323. https://doi.org/10.1136/jnnp-2014-309870

Higher mortality in patients with right hemispheric intracerebral haemorrhage : INTERACT1 and 2. / INTERACT Investigators; Sato, Shoichiro; Heeley, E; Arima, H; Delcourt, Candice; Hirakawa, Yoichiro; Pamidimukkala, Vijaya; Li, Zhendong; Tao, Qingling; Xu, Yuehong; Hennerici, Michael G; Robinson, Thompson; Tzourio, Christophe; Lindley, Richard I; Chalmers, J; Anderson, C S; Anderson, C S; Huang, Y; Wang, J G; Arima, H; Neal, B; Peng, B; Heeley, E; Skulina, C; Parsons, M W; Kim, J S; Tao, Q L; Li, Y C; Jiang, J D; Tai, L W; Zhang, L J; Xu, E; Cheng, Y; Heritier, S; Morgenstern, L B; Chalmers, J.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 12, 12.2015, p. 1319-1323.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Higher mortality in patients with right hemispheric intracerebral haemorrhage

T2 - INTERACT1 and 2

AU - INTERACT Investigators

AU - Sato, Shoichiro

AU - Heeley, E

AU - Arima, H

AU - Delcourt, Candice

AU - Hirakawa, Yoichiro

AU - Pamidimukkala, Vijaya

AU - Li, Zhendong

AU - Tao, Qingling

AU - Xu, Yuehong

AU - Hennerici, Michael G

AU - Robinson, Thompson

AU - Tzourio, Christophe

AU - Lindley, Richard I

AU - Chalmers, J

AU - Anderson, C S

AU - Huang, Y

AU - Wang, J G

AU - Arima, H

AU - Neal, B

AU - Peng, B

AU - Heeley, E

AU - Skulina, C

AU - Parsons, M W

AU - Kim, J S

AU - Tao, Q L

AU - Li, Y C

AU - Jiang, J D

AU - Tai, L W

AU - Zhang, L J

AU - Xu, E

AU - Cheng, Y

AU - Heritier, S

AU - Morgenstern, L B

AU - Chalmers, J

AU - De Raedt, Sylvie

AU - Brouns, Raf

AU - De Smedt, Ann

AU - De Keyser, Jacques

AU - Van Hooff, Robbert-Jan Roderick

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2015/12

Y1 - 2015/12

N2 - BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

AB - BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

KW - Aged

KW - Blood Pressure/drug effects

KW - Cause of Death

KW - Cerebral Hemorrhage/mortality

KW - Disability Evaluation

KW - Endpoint Determination

KW - Female

KW - Functional Laterality

KW - Glasgow Coma Scale

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Prognosis

KW - Survivors

KW - Treatment Outcome

U2 - 10.1136/jnnp-2014-309870

DO - 10.1136/jnnp-2014-309870

M3 - Article

C2 - 25589782

VL - 86

SP - 1319

EP - 1323

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 12

ER -

Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2

Abstract

Bibliographical note

Keywords

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