Highly stereoselective one-pot construction of trisubstituted tetrahydro-beta-carboline-fused diketopiperazines: a synthetic route towards cialis analogues: IF 3.84

Mouhamad Jida, Dirk Tourwe, Steven Ballet

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Abstract

A facile and efficient synthetic method for the stereoselective preparation of trisubstituted tetrahydro-beta-carboline-fused diketopiperazine derivatives is reported. The methodology represents a one-pot four-step reaction, employing the Ugi four-component condensation which is followed by a Boc-deprotection, a Pictet-Spengler reaction and a final lactamization. All THBC-DKPs were obtained in good yields and excellent diastereomeric excess.
Original languageEnglish
Pages (from-to)38159-38163
Number of pages5
JournalRSC Advances
Volume4
Publication statusPublished - 2014

Keywords

  • pictet-spengler reaction

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