Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats

Dimitri De Bundel; Najat Aourz; Foteini Kiagiadaki; Ralph Clinckers; Daniel Hoyer; Andreas Kastellakis; Yvette Michotte; Kyriaki Thermos; Ilse Julia Smolders

Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats

Dimitri De Bundel, Najat Aourz, Foteini Kiagiadaki, Ralph Clinckers, Daniel Hoyer, Andreas Kastellakis, Yvette Michotte, Kyriaki Thermos, Ilse Julia Smolders

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Somatostatin-14 (SRIF-14) exerts anticonvulsive effects in several rat seizure models, generally attributed to sst(2) receptor activation. Whereas sst(1) immunoreactivity has been localized to both polymorphic interneurons and principal cells in the rat hippocampus, its potential role as an inhibitory autoreceptor or as a receptor involved in mediating anticonvulsive actions remains unknown. We showed that intrahippocampal administration of the sst(1) antagonist SRA880 (1 microM) induced a robust increase in hippocampal SST-14 levels without affecting gamma-aminobutyric acid levels in conscious rats, indicating that the sst(1) receptor acts as an inhibitory autoreceptor. SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14.

Original language	English
Pages (from-to)	254-258
Journal	Neuroreport
Volume	21
Issue number	4
Publication status	Published - 2010

Keywords

autoreceptor, hippocampus, pilocarpine, rat

Cite this

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title = "Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats",

abstract = "Somatostatin-14 (SRIF-14) exerts anticonvulsive effects in several rat seizure models, generally attributed to sst(2) receptor activation. Whereas sst(1) immunoreactivity has been localized to both polymorphic interneurons and principal cells in the rat hippocampus, its potential role as an inhibitory autoreceptor or as a receptor involved in mediating anticonvulsive actions remains unknown. We showed that intrahippocampal administration of the sst(1) antagonist SRA880 (1 microM) induced a robust increase in hippocampal SST-14 levels without affecting gamma-aminobutyric acid levels in conscious rats, indicating that the sst(1) receptor acts as an inhibitory autoreceptor. SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14.",

keywords = "autoreceptor, hippocampus, pilocarpine, rat",

author = "{De Bundel}, Dimitri and Najat Aourz and Foteini Kiagiadaki and Ralph Clinckers and Daniel Hoyer and Andreas Kastellakis and Yvette Michotte and Kyriaki Thermos and Smolders, {Ilse Julia}",

year = "2010",

language = "English",

volume = "21",

pages = "254--258",

journal = "Neuroreport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. / De Bundel, Dimitri ; Aourz, Najat; Kiagiadaki, Foteini; Clinckers, Ralph; Hoyer, Daniel; Kastellakis, Andreas; Michotte, Yvette; Thermos, Kyriaki; Smolders, Ilse Julia.

In: Neuroreport, Vol. 21, No. 4, 2010, p. 254-258.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats

AU - De Bundel, Dimitri

AU - Aourz, Najat

AU - Kiagiadaki, Foteini

AU - Clinckers, Ralph

AU - Hoyer, Daniel

AU - Kastellakis, Andreas

AU - Michotte, Yvette

AU - Thermos, Kyriaki

AU - Smolders, Ilse Julia

PY - 2010

Y1 - 2010

N2 - Somatostatin-14 (SRIF-14) exerts anticonvulsive effects in several rat seizure models, generally attributed to sst(2) receptor activation. Whereas sst(1) immunoreactivity has been localized to both polymorphic interneurons and principal cells in the rat hippocampus, its potential role as an inhibitory autoreceptor or as a receptor involved in mediating anticonvulsive actions remains unknown. We showed that intrahippocampal administration of the sst(1) antagonist SRA880 (1 microM) induced a robust increase in hippocampal SST-14 levels without affecting gamma-aminobutyric acid levels in conscious rats, indicating that the sst(1) receptor acts as an inhibitory autoreceptor. SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14.

AB - Somatostatin-14 (SRIF-14) exerts anticonvulsive effects in several rat seizure models, generally attributed to sst(2) receptor activation. Whereas sst(1) immunoreactivity has been localized to both polymorphic interneurons and principal cells in the rat hippocampus, its potential role as an inhibitory autoreceptor or as a receptor involved in mediating anticonvulsive actions remains unknown. We showed that intrahippocampal administration of the sst(1) antagonist SRA880 (1 microM) induced a robust increase in hippocampal SST-14 levels without affecting gamma-aminobutyric acid levels in conscious rats, indicating that the sst(1) receptor acts as an inhibitory autoreceptor. SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14.

KW - autoreceptor, hippocampus, pilocarpine, rat

M3 - Article

VL - 21

SP - 254

EP - 258

JO - Neuroreport

JF - Neuroreport

SN - 0959-4965

IS - 4

ER -

Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats

Abstract

Keywords

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