Purpose: In several in-vitro research studies was shown that hypertonic salt water solution has an enhancing effect on mucociliary beat frequency. Nevertheless nose sprays with isotonic salt water solution are more popular on the market. They are sold as wellness products but also for care and cure of various nose diseases. Methods: In a randomized double-blind trial with n=20 healthy volunteers the effect of a 7-day application of hypertonic sodium chloride solution (3% NaCl) measured by saccharine-clearance-test (SCT), rhinomanometry and questionnaires was evaluated in comparison to a isotonic salt solution (0,9% NaCl). Results: The SCT showed in both groups no significant change. In rhinomanometry a significant higher rate of airflow could be measured after a 7 day period of applicating hypertonic spray. The volunteers evaluated the hypertonic solution as more effective in regard their nasal airflow. Conclusion: Although in this RCT an effect on mucociliary clearance could not be detected after a 7 day application of salt water nose spray, a hypertonic spray showed objectively and subjectively a significant influence on nasal airflow. This effect could be of interest eg. in reducing the use of decongestive nose sprays.