Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

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Abstract

The important role of tumor microenvironmental elements in determining tumor progression and metastasis has been firmly established. In particular, the presence and activity profile of tumor-infiltrating immune cells may be associated with the outcome of the disease and may predict responsiveness to (immuno)therapy. Indeed, while some immune cell types, such as macrophages, support cancer cell outgrowth and mediate therapy resistance, the presence of activated CD8+ T cells is usually indicative of a better prognosis. It is therefore of the utmost interest to obtain a full picture of the immune infiltrate in tumors, either as a prognostic test, as a way to stratify patients to maximize therapeutic success, or as therapy follow-up. Hence, the non-invasive imaging of these cells is highly warranted, with biologics being prime candidates to achieve this goal.
Original languageEnglish
Article number114239
JournalAdvanced Drug Delivery Reviews
Volume184
DOIs
Publication statusPublished - May 2022

Bibliographical note

Funding Information:
SA is supported by a doctoral grant from FWO. TWMDG and JAVG are supported by the EU/EFPIA/Innovative Medicines Initiative 2 Joint Undertaking Immune-Image grant no 831514. JAVG also received funding for related work from FWO, Kom op tegen Kanker and Stichting tegen Kanker.

Publisher Copyright:
© 2022 The Authors

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