Immune modulation by genetic modification of dendritic cells with lentiviral vectors

T. Liechtenstein, N. Perez-Janices, C. Bricogne, A. Lanna, Inès Dufait, Cleo Goyvaerts, R. Laranga, A. Padella, F. Arce, M. Baratchian, N. Ramirez, N. Lopez, G. Kochan, I. Blanco-Luquin, D. Guerrero-Setas, Karine Breckpot, D. Escors

Research output: Contribution to journalScientific review

14 Citations (Scopus)

Abstract

Our work over the past eight years has focused on the use of HIV-1 lentiviral vectors (lentivectors) for the genetic modification of dendritic cells (DCs) to control their functions in immune modulation. DCs are key professional antigen presenting cells which regulate the activity of most effector immune cells, including T, B and NK cells. Their genetic modification provides the means for the development of targeted therapies towards cancer and autoimmune disease. We have been modulating with lentivectors the activity of intracellular signalling pathways and co-stimulation during antigen presentation to T cells, to fine-tune the type and strength of the immune response. In the course of our research, we have found unexpected results such as the surprising immunosuppressive role of anti-viral signalling pathways, and the close link between negative co-stimulation in the immunological synapse and T cell receptor trafficking. Here we review our major findings and put them into context with other published work.
Original languageEnglish
Pages (from-to)1-15
JournalVirus Research
Volume176
Issue number1-2
DOIs
Publication statusPublished - Sep 2013

Keywords

  • immunology
  • genetic modification
  • dendritic cells
  • lentiviral vectors

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