In vitro models to study the possible endocrine disrupting activity of migration products from plastic baby bottles

Coraline Simon, Matthias Onghena, Adrian Covaci, Els Van Hoeck, Joris Van Loco, Marc Elskens, Kersten Van Langenhove, Tara Vandermarken, Heidi Demaegdt, Birgit Mertens, Karine Vandermeiren, Mi Scippo

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

Introduction

Bisphenol A (BPA) is documented in several studies to be a well-known source of food contamination [1]. The measurements of BPA in human fluids and tissues highlighted that its presence in food constitutes the primary route of human exposure [2]. Some studies showed that BPA, which can act as an hormone and disrupt normal endocrine function, may be associated to several health problems and diseases.
Recently, the European food safety authority conducted a risk assessment on BPA and concluded that though studies relating to potential health hazards associated with BPA are still uncertain, they are suggesting a potential negative effect on human body. Following that screening assessment, the European Union took a series of measures, including a banned for the import and saleof PC baby bottles to reduce BPA exposure to infants [3].
Plastic alternatives to polycarbonate, which have massively appeared on Belgian market, are polypropylene (PP), silicone, polyamide (PA) and polyethersulphone (PES). Although there are several studies on BPA migration from polycarbonate into foodstuff under a variety of condition [4,5,6], there is very few information about consequences on human health of the potential chemical migrant from PC alternatives, including bottles commonly labelled "BPA free". In a recent opinion (No. 8697, 11.03.2010), the Belgian Superior Health Council issued its concern regarding the currently used alternatives to PC. Furthermore, they asked to investigate the possible risks associated with the use of these alternatives.
To know if these alternatives are safe to use, the activity on several receptor of chemical migrating from PC alternatives, identified by the group of Simoneau [7], were evaluated. In this paper, the activity of pure substances is screened using a reporter gene assay. In this way, the screening method acts as a filter to select those substances that present a risk for human health and need to be characterized by further investigation.
Original languageEnglish
Title of host publicationDioxin 2014, 34th International Symposium on Halogenated Persistent Organic Pollutants
Number of pages4
Publication statusPublished - 2014
Event34th International Symposium on Halogenated Persistent Organic Pollutants - Madrid, Spain
Duration: 31 Aug 20145 Sep 2014

Conference

Conference34th International Symposium on Halogenated Persistent Organic Pollutants
Abbreviated titleDIOXIN 2014
Country/TerritorySpain
CityMadrid
Period31/08/145/09/14

Keywords

  • BPA
  • babybottle
  • endocrine
  • mirgation

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