Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks.

A. Fucic; J. Katic; E. Fthenou; M. Kogevinas; D. Plavec; J. Koppel; D. Batinic; G. Chalkiadaki; L. Chatzi; R. Lasan; Jos Kleinjans; Micheline Volders

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks.

A. Fucic, J. Katic, E. Fthenou, M. Kogevinas, D. Plavec, J. Koppel, D. Batinic, G. Chalkiadaki, L. Chatzi, R. Lasan, Jos Kleinjans, Micheline Volders

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with

Original language	English
Pages (from-to)	110-115
Number of pages	6
Journal	Reproductive Toxicology
Issue number	42
Publication status	Published - 1 Dec 2013

Keywords

Binuclear lymphocyte
C-FISH
Micronucleus assay
Mononuclear lymphocyte
Mother
Newborn
Nuclear division index

Cite this

Fucic, A., Katic, J., Fthenou, E., Kogevinas, M., Plavec, D., Koppel, J., Batinic, D., Chalkiadaki, G., Chatzi, L., Lasan, R., Kleinjans, J., & Volders, M. (2013). Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. Reproductive Toxicology, (42), 110-115.

Fucic, A. ; Katic, J. ; Fthenou, E. ; Kogevinas, M. ; Plavec, D. ; Koppel, J. ; Batinic, D. ; Chalkiadaki, G. ; Chatzi, L. ; Lasan, R. ; Kleinjans, Jos ; Volders, Micheline. / Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. In: Reproductive Toxicology. 2013 ; No. 42. pp. 110-115.

@article{e6c43d6002034f02bab5d5995a9df58a,

title = "Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks.",

abstract = "Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with",

keywords = "Binuclear lymphocyte, C-FISH, Micronucleus assay, Mononuclear lymphocyte, Mother, Newborn, Nuclear division index",

author = "A. Fucic and J. Katic and E. Fthenou and M. Kogevinas and D. Plavec and J. Koppel and D. Batinic and G. Chalkiadaki and L. Chatzi and R. Lasan and Jos Kleinjans and Micheline Volders",

year = "2013",

month = dec,

day = "1",

language = "English",

pages = "110--115",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

number = "42",

}

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. / Fucic, A.; Katic, J.; Fthenou, E.; Kogevinas, M.; Plavec, D.; Koppel, J.; Batinic, D.; Chalkiadaki, G.; Chatzi, L.; Lasan, R.; Kleinjans, Jos; Volders, Micheline.

In: Reproductive Toxicology, No. 42, 01.12.2013, p. 110-115.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks.

AU - Fucic, A.

AU - Katic, J.

AU - Fthenou, E.

AU - Kogevinas, M.

AU - Plavec, D.

AU - Koppel, J.

AU - Batinic, D.

AU - Chalkiadaki, G.

AU - Chatzi, L.

AU - Lasan, R.

AU - Kleinjans, Jos

AU - Volders, Micheline

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with

AB - Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with

KW - Binuclear lymphocyte

KW - C-FISH

KW - Micronucleus assay

KW - Mononuclear lymphocyte

KW - Mother

KW - Newborn

KW - Nuclear division index

M3 - Article

SP - 110

EP - 115

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - 42

ER -

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks.

Abstract

Keywords

Fingerprint

Cite this