Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity

Pieter Meysman; Nicolas De Neuter; Esther Bartholomeus; George Elias; Johan Van den Bergh; Marie-Paule Emonds; Geert W Haasnoot; Steven Heynderickx; Johan Wens; Nele R Michels; Julien Lambert; Eva Lion; Frans H J Claas; Herman Goossens; Evelien Smits; Pierre Van Damme; Viggo Van Tendeloo; Philippe Beutels; Arvid Suls; Geert Mortier; Kris Laukens; Benson Ogunjimi

doi:10.1007/s00251-017-1047-x

Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity

Pieter Meysman, Nicolas De Neuter, Esther Bartholomeus, George Elias, Johan Van den Bergh, Marie-Paule Emonds, Geert W Haasnoot, Steven Heynderickx, Johan Wens, Nele R Michels, Julien Lambert, Eva Lion, Frans H J Claas, Herman Goossens, Evelien Smits, Pierre Van Damme, Viggo Van Tendeloo, Philippe Beutels, Arvid Suls, Geert MortierKris Laukens, Benson Ogunjimi

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.

Original language	English
Pages (from-to)	363-372
Number of pages	10
Journal	Immunogenetics
Volume	70
Issue number	6
DOIs	https://doi.org/10.1007/s00251-017-1047-x
Publication status	Published - Jun 2018

Keywords

Herpes zoster
HLA association
MHC peptide affinity
Varicella zoster virus

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Meysman, P., De Neuter, N., Bartholomeus, E., Elias, G., Van den Bergh, J., Emonds, M.-P., Haasnoot, G. W., Heynderickx, S., Wens, J., Michels, N. R., Lambert, J., Lion, E., Claas, F. H. J., Goossens, H., Smits, E., Van Damme, P., Van Tendeloo, V., Beutels, P., Suls, A., ... Ogunjimi, B. (2018). Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity. Immunogenetics, 70(6), 363-372. https://doi.org/10.1007/s00251-017-1047-x

@article{90ec6c0af1954c97abd0958d1f874bb6,

title = "Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity",

abstract = "Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.",

keywords = "Herpes zoster, HLA association, MHC peptide affinity, Varicella zoster virus",

author = "Pieter Meysman and {De Neuter}, Nicolas and Esther Bartholomeus and George Elias and {Van den Bergh}, Johan and Marie-Paule Emonds and Haasnoot, {Geert W} and Steven Heynderickx and Johan Wens and Michels, {Nele R} and Julien Lambert and Eva Lion and Claas, {Frans H J} and Herman Goossens and Evelien Smits and {Van Damme}, Pierre and {Van Tendeloo}, Viggo and Philippe Beutels and Arvid Suls and Geert Mortier and Kris Laukens and Benson Ogunjimi",

year = "2018",

month = jun,

doi = "10.1007/s00251-017-1047-x",

language = "English",

volume = "70",

pages = "363--372",

journal = "Immunogenetics",

issn = "0093-7711",

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Meysman, P, De Neuter, N, Bartholomeus, E, Elias, G, Van den Bergh, J, Emonds, M-P, Haasnoot, GW, Heynderickx, S, Wens, J, Michels, NR, Lambert, J, Lion, E, Claas, FHJ, Goossens, H, Smits, E, Van Damme, P, Van Tendeloo, V, Beutels, P, Suls, A, Mortier, G, Laukens, K & Ogunjimi, B 2018, 'Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity', Immunogenetics, vol. 70, no. 6, pp. 363-372. https://doi.org/10.1007/s00251-017-1047-x

TY - JOUR

T1 - Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity

AU - Meysman, Pieter

AU - De Neuter, Nicolas

AU - Bartholomeus, Esther

AU - Elias, George

AU - Van den Bergh, Johan

AU - Emonds, Marie-Paule

AU - Haasnoot, Geert W

AU - Heynderickx, Steven

AU - Wens, Johan

AU - Michels, Nele R

AU - Lambert, Julien

AU - Lion, Eva

AU - Claas, Frans H J

AU - Goossens, Herman

AU - Smits, Evelien

AU - Van Damme, Pierre

AU - Van Tendeloo, Viggo

AU - Beutels, Philippe

AU - Suls, Arvid

AU - Mortier, Geert

AU - Laukens, Kris

AU - Ogunjimi, Benson

PY - 2018/6

Y1 - 2018/6

N2 - Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.

AB - Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.

KW - Herpes zoster

KW - HLA association

KW - MHC peptide affinity

KW - Varicella zoster virus

UR - http://www.scopus.com/inward/record.url?scp=85035805401&partnerID=8YFLogxK

U2 - 10.1007/s00251-017-1047-x

DO - 10.1007/s00251-017-1047-x

M3 - Article

C2 - 29196796

SN - 0093-7711

VL - 70

SP - 363

EP - 372

JO - Immunogenetics

JF - Immunogenetics

IS - 6

ER -

Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity

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Keywords

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