Induction of tumor cell death through targeted introduction of the pro-apoptotic gene, tSMAC

Joeri Pen, Perpetua Emeagi, Carlo Heirman, Joeri Aerts, Kris Thielemans, Karine Breckpot

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract (Book)

Abstract

PD-L1 on melanoma cells impairs the function of TIL. However, whereas it has been reported that PD-L1 on tumor cells has an anti-apoptotic effect, this is not the case for at least 1087-mel, challenging our current knowledge on the anti-apoptotic effect of PD-L1.
Lentiviruses encoding tSMAC controlled by the huTYR specifically induce apoptosis of melanoma cells. In the future, we will evaluate whether the resulting apoptotic bodies (tumor antigens) are taken up and processed by dendritic cells and whether this results in activation (lentiviral component) and presentation of tumor antigens to effector T cells.
Original languageEnglish
Title of host publication2nd European Congress of Immunology, Berlin, Germany
Publication statusPublished - 13 Sep 2009
Event2nd European Congress of Immunology - Berlin, Germany
Duration: 13 Sep 200916 Sep 2009

Conference

Conference2nd European Congress of Immunology
CountryGermany
CityBerlin
Period13/09/0916/09/09

Keywords

  • tumor
  • apoptosis
  • tSMAC

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