Inhibition of gap junctional intercellular communication by toxic metals

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29 Citations (Scopus)


Being ubiquitous in the environment, humans are continuously exposed to metals. Although some metallic elements play key roles in human physiology, most metals are redundant and are actually hazardous to mankind. A common event in the toxicological cascade triggered by non-essential metals concerns the abrogation of cellular signalling. The current paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminium, lead, nickel, vanadium and indium on direct intercellular communication mediated by gap junctions. Particular attention is paid to the mechanistic basis of this deleterious biological outcome.
Original languageEnglish
Pages (from-to)1862-1867
Number of pages6
JournalChemical Research in Toxicology
Publication statusPublished - 1 Dec 2010


  • metals
  • gap junction
  • connexin
  • toxicity


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