Insights into the effects of dietary omega-6/omega-3 polyunsatu-rated fatty acid (Pufa) ratio on oxidative metabolic pathways of oncological bone disease and global health

Geir Bjørklund, Maryam Dadar, Monica Daniela Doşa, Salvatore Chirumbolo, Joeri J Pen

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Various nutrients have been designated as antioxidants, with a possible effect on diseases like cancer. This is partly due to their effect on prostaglandins, thereby affecting local pathological metabolic acidosis. This paper aims to summarize the culprit pathophysi-ological mechanisms involved, with a focus on the bone microenvironment. The omega-6/omega-3 PUFA ratio is particularly investigated for its antioxidative effects, countering these pathways to fight the disease. This feature is looked at concerning its impact on health in general, with a particular focus on malignant bone metastasis.

Original languageEnglish
Pages (from-to)1672-1682
Number of pages11
JournalCurrent Medicinal Chemistry
Volume28
Issue number9
Early online date26 Apr 2020
DOIs
Publication statusPublished - 1 Jan 2021

Bibliographical note

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