Interaction between microtubule inhibitors and ionizing radiation

G. Storme, W. Distelmans, W. De Neve, M. Mareel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

B. DRUGS The Vinca alkaloids vinblastine (VLB) and vindesine (VDS), documented MTI known Tubulozole, a synthetic MTI, I3 exists in two isomeric forms: one active, tubulozole-cis (T-C), and one inactive, tubulozole-trans (T-T), on microtubules. T-T has no antiturnor activity. Therefore, tubulozole is a most appropriate compound to use to analyze MTIspecific effects. T-C has been shown to be effective on MO, cellsI4 and on 3LL cells.

Original languageEnglish
Title of host publicationAntitumor Drug Radiation Interactions
PublisherCRC Press
Pages107-124
Number of pages18
ISBN (Electronic)9781351078160
ISBN (Print)0849346207, 9781315890616
DOIs
Publication statusPublished - 1 Jan 2018

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