Interaction between microtubule inhibitors and ionizing radiation

G. Storme, W. Distelmans, W. De Neve, M. Mareel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


B. DRUGS The Vinca alkaloids vinblastine (VLB) and vindesine (VDS), documented MTI known Tubulozole, a synthetic MTI, I3 exists in two isomeric forms: one active, tubulozole-cis (T-C), and one inactive, tubulozole-trans (T-T), on microtubules. T-T has no antiturnor activity. Therefore, tubulozole is a most appropriate compound to use to analyze MTIspecific effects. T-C has been shown to be effective on MO, cellsI4 and on 3LL cells.

Original languageEnglish
Title of host publicationAntitumor Drug Radiation Interactions
PublisherCRC Press
Number of pages18
ISBN (Electronic)9781351078160
ISBN (Print)0849346207, 9781315890616
Publication statusPublished - 1 Jan 2018


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