Jumping Exercise Combined With Collagen Supplementation Preserves Bone Mineral Density in Elite Cyclists

Luuk Hilkens, Nick van Schijndel, Vera C R Weijer, Lieselot Decroix, Judith Bons, Luc J C van Loon, Jan-Willem van Dijk

Research output: Contribution to journalArticlepeer-review

Abstract

This study assessed the effect of combined jump training and collagen supplementation on bone mineral density (BMD) in elite road-race cyclists. In this open-label, randomized study with two parallel groups, 36 young (21 ± 3 years) male (n = 8) and female (n = 28) elite road-race cyclists were allocated to either an intervention (INT: n = 18) or a no-treatment control (CON: n = 18) group. The 18-week intervention period, conducted during the off-season, comprised five 5-min bouts of jumping exercise per week, with each bout preceded by the ingestion of 15 g hydrolyzed collagen. Before and after the intervention, BMD of various skeletal sites and trabecular bone score of the lumbar spine were assessed by dual-energy X-ray absorptiometry, along with serum bone turnover markers procollagen Type I N propeptide and carboxy-terminal cross-linking telopeptide of Type I collagen. BMD of the femoral neck decreased in CON (from 0.789 ± 0.104 to 0.774 ± 0.095 g/cm2), while being preserved in INT (from 0.803 ± 0.058 to 0.809 ± 0.066 g/cm2; Time × Treatment, p < .01). No differences between treatments were observed for changes in BMD at the total hip, lumbar spine, and whole body (Time × Treatment, p > .05 for all). Trabecular bone score increased from 1.38 ± 0.08 to 1.40 ± 0.09 in CON and from 1.46 ± 0.08 to 1.47 ± 0.08 in INT, respectively (time effect: p < .01), with no differences between treatments (Time × Treatment: p = .33). Serum procollagen Type I N propeptide concentrations decreased to a similar extent in CON (83.6 ± 24.8 to 71.4 ± 23.1 ng/ml) and INT (82.8 ± 30.7 to 66.3 ± 30.6; time effect, p < .001; Time × Treatment, p = .22). Serum carboxy-terminal cross-linking telopeptide of Type I collagen concentrations did not change over time, with no differences between treatments (time effect, p = .08; Time × Treatment, p = .58). In conclusion, frequent short bouts of jumping exercise combined with collagen supplementation beneficially affects femoral neck BMD in elite road-race cyclists.

Original languageEnglish
Pages (from-to)38-47
Number of pages10
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Volume34
Issue number1
Early online date2023
DOIs
Publication statusPublished - 1 Jan 2024

Bibliographical note

Funding Information:
The authors are grateful to the cyclists who participated in this study and the support provided by the staff members of the cycling teams. The authors also thank Esther van der Burg for her help with data collection. Author Contributions: Study design: Hilkens, van Dijk. Data collection: Hilkens, van Schijndel, Weijer. Data analysis: Hilkens. Data interpretation and manuscript preparation: Hilkens, Decroix, Bons, van Loon, van Dijk. Data interpretation and discussion of the manuscript for important intellectual content and approved the final manuscript: All authors. Funding: The work of Hilkens and van Dijk on this topic is part of the Eat2Move project and sponsored by a grant from the Province of Gelderland, the Netherlands. The collagen supplements were provided free of charge by Niche4Health, he Netherlands. Conflict of Interest: No conflicts of interest, financial or otherwise, related to the current manuscript are declared by the authors. The results of this study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. Ethics Approval: This study was approved by Medical Ethical Committee Zuyd, the Netherlands, and conformed to the standards for the use of human participants as outlined in the most recent version of the Declaration of Helsinki. The study was registered at the Netherlands Trial Registry (https://clinicaltrialregister.nl) as NL9770.

Funding Information:
The authors are grateful to the cyclists who participated in this study and the support provided by the staff members of the cycling teams. The authors also thank Esther van der Burg for her help with data collection. Author Contributions: Study design: Hilkens, van Dijk. Data collection: Hilkens, van Schijndel, Weijer. Data analysis: Hilkens. Data interpretation and manuscript preparation: Hilkens, Decroix, Bons, van Loon, van Dijk. Data interpretation and discussion of the manuscript for important intellectual content and approved the final manuscript: All authors. Funding: The work of Hilkens and van Dijk on this topic is part of the Eat2Move project and sponsored by a grant from the Province of Gelder-land, the Netherlands. The collagen supplements were provided free of charge by Niche4Health, he Netherlands. Conflict of Interest: No conflicts of interest, financial or otherwise, related to the current manuscript are declared by the authors. The results of this study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. Ethics Approval: This study was approved by Medical Ethical Committee Zuyd, the Netherlands, and conformed to the standards for the use of human participants as outlined in the most recent version of the Declaration of Helsinki. The study was registered at the Netherlands Trial Registry (https://clinicaltrialregister.nl) as NL9770.

Publisher Copyright:
© 2024 The Authors.

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