Klinefelter syndrome: Urological aspects

V. De Coninck, D. Michielsen

Research output: Contribution to journalArticlepeer-review


More than half of the men with Klinefelter syndrome (KS) consults a urologist, mainly for a decreased penile size or sexual problems, like a decreased libido, erectile dysfunction or hypospermia. These urological signs and symptoms are not the result of the chromosomal aberration, but the consequence of the hypogonadal status. Recent studies with a functional MRI revealed the trophic role of testosterone on the "emotional brain". Furthermore, this hormone influences the erectile function by enhancing endothelial and neurological pathways. In addition, testosterone increases the sperm volume by stimulating the glandular cells of the seminal vesicles and the prostate. Therefore, testosterone replacement therapy should be started as soon as possible in men with KS and documented hypogonadism to prevent or treat these urological symptoms caused by the hypogonadal status.

Translated title of the contributionKlinefelter syndrome: Urological aspects
Original languageDutch
Pages (from-to)331-334
Number of pages4
JournalTijdschrift voor Geneeskunde
Issue number5
Publication statusPublished - 1 Mar 2015


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