LH concentrations do not correlate with pregnancy in rFSH/GnRH antagonist cycles

Kevin Doody, Paul Devroey, Keith Gordon, Han Witjes, B. Mannaerts

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The possible relationship between endogenous LH concentrations and clinical outcome was evaluated in 750 patients treated with a standardized gonadotrophin-releasing hormone (GnRH) antagonist and recombinant FSH (rFSH)-only protocol. Serum LH concentrations were measured during stimulation by a central laboratory and patients were stratified into quantiles of P75. The P25 values were 3.38IU/l, 0.93IU/l, and 0.91IU/l on stimulation days 1, 5, and 8, respectively. The ongoing pregnancy rates per started cycle of patients within the P75 subsets and ranged in the various subsets between 35.0% and 39.5%. In keeping with previous, smaller studies, these findings demonstrate that in good prognosis, non-obese patients endogenous LH in a GnRH antagonist protocol is able to support treatment with rFSH only. Copyright © 2009 Reproductive Healthcare Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)565-567
Number of pages3
JournalReprod Biomed Online
Volume20
Publication statusPublished - 2010

Keywords

  • endogenous LH
  • GnRH antagonist protocol
  • IVF
  • rFSH

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