Limited ability of circulating anti-Müllerian hormone to predict dominant follicular recruitment in PCOS women treated with clomiphene citrate: a comparison of two different assays.

Alberto Vaiarelli, Panagiotis Drakopoulos, Christophe Blockeel, Michel De Vos, Arne van de Vijver, Michel Camus, Stefan Cosyns, Herman Tournaye, Nikolaos Polyzos

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The present retrospective cohort study was conducted to investigate whether serum anti-Müllerian hormone (AMH) levels, determined by either the Immunotech (IOT) or the second generation (Gen II) assay, can predict follicular recruitment in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction with clomiphene citrate (CC). Patients received 50 mg CC daily for ovulation induction followed by natural intercourse or intrauterine insemination. Overall, 84 women had their serum AMH levels tested before treatment [42 patients with Immunotech (IOT), and 42 patients with the Gen II assay]. The primary outcome was to determine dominant follicle (>10 mm) recruitment in relation to AMH levels. Thirty-three (79%) patients in the IOT and 34 (81%) patients in the Gen II assay group developed a dominant follicle within 15 days after initiation of CC. Circulating AMH levels did not differ between women with or without dominant follicular recruitment in the both groups. By using either the AMH IOT or the Gen II assay, serum AMH levels were not predictive of the development of a dominant follicle. In conclusion, serum AMH levels measured by IOT or Gen II assay, has limited value to predict PCOS patients who will develop a dominant follicle following ovulation induction with CC.
Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalGynecological Endocrinology
Volume32
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • AMH
  • AMH assay
  • PCOS
  • dominant follicle
  • ovulation

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