Lipid nanoparticles

Stefaan De Koker; Sanne Bevers; Raymond Schiffelers; Sander A A Kooijmans

Lipid nanoparticles

Stefaan De Koker (Inventor), Sanne Bevers (Inventor), Raymond Schiffelers (Inventor), Sander A A Kooijmans (Inventor)

Vrije Universiteit Brussel

Research output: Patent

Abstract

The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.

Original language	English
Patent number	EP4093373
Publication status	Published - 2022

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title = "Lipid nanoparticles",

abstract = "The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.",

author = "{De Koker}, Stefaan and Sanne Bevers and Raymond Schiffelers and Kooijmans, {Sander A A}",

year = "2022",

language = "English",

type = "Patent",

note = "EP4093373",

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TY - PAT

T1 - Lipid nanoparticles

AU - De Koker, Stefaan

AU - Bevers, Sanne

AU - Schiffelers, Raymond

AU - Kooijmans, Sander A A

PY - 2022

Y1 - 2022

N2 - The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.

AB - The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.

UR - http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP4093373&F=0

M3 - Patent

M1 - EP4093373

ER -

Lipid nanoparticles

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IWTOO24: Baekeland mandate: preclinical development of an mRNA cancer vaccine for intravenous administration

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Lipid nanoparticles

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IWTOO24: Baekeland mandate: preclinical development of an mRNA cancer vaccine for intravenous administration

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