Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions.

Peter Tompa, Lajos Kalmar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication.
Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of Molecular Biology
Issue number424
Publication statusPublished - 10 Sep 2012

Keywords

  • Disorder Protein

Fingerprint Dive into the research topics of 'Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions.'. Together they form a unique fingerprint.

Cite this