May gender influence real blood concentrations of propofol during TCI

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Background and Goal of Study: The influence of gender on anaesthesia remains poorly understood, nevertheless there is growing evidence suggesting that gender may be an independent factor influencing the PKs. The purpose of this study was to investigate the influence of gender on real blood propofol concentrations during TCI. Materials and Methods: 20 euthyroid patients, aged 18-70 year, ASA I to II, scheduled for elective thyroid surgery were included. Level of hypnosis was monitored with Neurosense monitor and analgesic level was monitored with an ANI index . A radial arterial catheter was inserted in the contralateral arm of infusion, for blood sampling and for continuous monitoring of BP and CO. A TCI of sufentanil was started with a target ef fect (Ce )of 0.3 ng/ml (PK Gepts) followed by the TCI of propofol, targeting a predicted blood concentration (Cp) of 4 μg/ml ( PK- Schnider). The Cp of propofol was increased or decreased if the neurowave index was >60 or <40 and the Ce of sufentanil was increased or decreased if the ANI was <50 or >70. Arterial blood samples were collected at at well defined timepoints. At each time point, the PE was calculated as PE(%) = (Cm-Cp)/Cpx100 where Cm and Cp are the measured and predicted blood concentrations. Results and Discussion: 7 men and 13 women were included in this study. No dif ference in age was found between men and women, 56.71 ( 11.07) and 55.38 (7.59) years respectively (P=0.754). Repeated measures ANOVA showed a significant drop in CO at 15 and 30 min af ter start TCI compared to baseline in women (p = 0.00004 and p =0.004) . On average women showed a significant higher PE (M= 58.93, SE 2.95) than men (M= 28.18, SE 3.88). PE increases slightly with increased sufentanil Ce and these increase was higher in women ( 14.16% vs 3.61% respectively). Light hypothermy had higher influence on PE in man compared to women (increase 11.12% vs 3.42%). An inverse relation between CO and propofol Cp may explain the higher bias observed in women. Conclusion(s): Gender seems to have an impact on propofol PKs in our thyroid population.
Original languageEnglish
Article number1AP12-10
Pages (from-to)46-47
Number of pages2
JournalEuropean Journal of Anaesthesiology
Issue numberes53
Publication statusPublished - 1 Jun 2015
EventEuroanaesthesia 2015 - Berlin Cube, Berlin, Germany
Duration: 30 May 20152 Jun 2015


  • gender influence
  • blood concentrations
  • Propofol
  • TCI


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