Measurement Properties of 4 Patient-Reported Outcome Measures to Assess Sleep Disturbance in Adults With Atopic Dermatitis

Donald K Lei, Muhammad Yousaf, Sherief R Janmohamed, Paras P Vakharia, Rishi Chopra, Rajeev Chavda, Sylvie Gabriel, Ryan Sacotte, Kevin R Patel, Vivek Singam, Robert Kantor, Derek Y Hsu, David Cella, Jonathan I Silverberg

Research output: Contribution to journalArticle


BACKGROUND: The ideal patient-reported outcome measure to assess sleep disturbance in atopic dermatitis (AD) has not been determined.

OBJECTIVE: We sought to determine the measurement properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire Mood and Sleep (PIQ-MS), Sleep Disturbance (SD), Sleep-Related Impairment (SRI), and Epworth Sleepiness Scale (ESS) in adults with AD.

METHODS: A prospective dermatology practice-based study was performed using questionnaires and evaluation by a dermatologist (n=611).

RESULTS: PIQ-MS, PROMIS SD, SRI, and ESS had good convergent validity with intensity and frequency of sleep disturbance, Patient-Oriented Eczema Measure, Eczema Area and Severity Index, total and objective-Scoring AD, Numerical Rating Scale of worst-itch and average-itch, and Dermatology Life Quality Index. PIQ-MS had significantly better correlations with other severity measures than the other sleep measures (Fisher z-scores, P≤0.007). PIQ-MS, and to lesser extent PROMIS SD, PROMIS SRI and ESS had good discriminant validity. All four sleep assessments showed fair responsiveness to change of severity of sleep-disturbance, AD and itch. PIQ-MS had the best reliability. PIQ-MS, PROMIS SD, SRI and ESS showed good internal consistency and were feasible for use in clinical practice.

CONCLUSIONS: PIQ-MS, followed by PROMIS SD, had the best construct validity and reliability in adult AD.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalContact Dermatitis
Issue number5
Publication statusPublished - 1 Sep 2020


  • Atopic Dermatitis
  • Patient Health Questionnaire 9
  • Patient Health Questionnaire 2
  • adults
  • depression

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