Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis

Jonathan I Silverberg; Brad Lee; Donald Lei; Muhammad Yousaf; Sherief R Janmohamed; Paras P Vakharia; Rishi Chopra; Rajeev Chavda; Sylvie Gabriel; Kevin R Patel; Vivek Singam; Robert Kantor; Derek Y Hsu

doi:10.1097/DER.0000000000000653

Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis

Jonathan I Silverberg, Brad Lee, Donald Lei, Muhammad Yousaf, Sherief R Janmohamed, Paras P Vakharia, Rishi Chopra, Rajeev Chavda, Sylvie Gabriel, Kevin R Patel, Vivek Singam, Robert Kantor, Derek Y Hsu

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND: Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms.

OBJECTIVE: We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted.

RESULTS: PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82).

CONCLUSIONS: PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.

Original language	English
Pages (from-to)	225-231
Number of pages <span style="color:red"p> <font size="1.5"> ✽ </span> </font>	7
Journal	Contact Dermatitis
Volume	32
Issue number	4
Early online date	1 Dec 2020
DOIs	https://doi.org/10.1097/DER.0000000000000653
Publication status	Published - 2021

Keywords

Atopic Dermatitis
depression
Patient Health Questionnaire-9 (PHQ9)
PHQ2
dermatology-practice based study

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10.1097/DER.0000000000000653

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Silverberg, J. I., Lee, B., Lei, D., Yousaf, M., Janmohamed, S. R., Vakharia, P. P., Chopra, R., Chavda, R., Gabriel, S., Patel, K. R., Singam, V., Kantor, R., & Hsu, D. Y. (2021). Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis. Contact Dermatitis, 32(4), 225-231. https://doi.org/10.1097/DER.0000000000000653

Silverberg, Jonathan I ; Lee, Brad ; Lei, Donald ; Yousaf, Muhammad ; Janmohamed, Sherief R ; Vakharia, Paras P ; Chopra, Rishi ; Chavda, Rajeev ; Gabriel, Sylvie ; Patel, Kevin R ; Singam, Vivek ; Kantor, Robert ; Hsu, Derek Y. / Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis. In: Contact Dermatitis. 2021 ; Vol. 32, No. 4. pp. 225-231.

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title = "Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis",

abstract = "BACKGROUND: Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms.OBJECTIVE: We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted.RESULTS: PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82).CONCLUSIONS: PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.",

keywords = "Atopic Dermatitis, depression, Patient Health Questionnaire-9 (PHQ9), PHQ2, dermatology-practice based study",

author = "Silverberg, {Jonathan I} and Brad Lee and Donald Lei and Muhammad Yousaf and Janmohamed, {Sherief R} and Vakharia, {Paras P} and Rishi Chopra and Rajeev Chavda and Sylvie Gabriel and Patel, {Kevin R} and Vivek Singam and Robert Kantor and Hsu, {Derek Y}",

year = "2021",

doi = "10.1097/DER.0000000000000653",

language = "English",

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Silverberg, JI, Lee, B, Lei, D, Yousaf, M, Janmohamed, SR, Vakharia, PP, Chopra, R, Chavda, R, Gabriel, S, Patel, KR, Singam, V, Kantor, R & Hsu, DY 2021, 'Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis', Contact Dermatitis, vol. 32, no. 4, pp. 225-231. https://doi.org/10.1097/DER.0000000000000653

Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis. / Silverberg, Jonathan I; Lee, Brad; Lei, Donald; Yousaf, Muhammad; Janmohamed, Sherief R; Vakharia, Paras P; Chopra, Rishi; Chavda, Rajeev; Gabriel, Sylvie; Patel, Kevin R; Singam, Vivek; Kantor, Robert; Hsu, Derek Y.

In: Contact Dermatitis, Vol. 32, No. 4, 2021, p. 225-231.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis

AU - Silverberg, Jonathan I

AU - Lee, Brad

AU - Lei, Donald

AU - Yousaf, Muhammad

AU - Janmohamed, Sherief R

AU - Vakharia, Paras P

AU - Chopra, Rishi

AU - Chavda, Rajeev

AU - Gabriel, Sylvie

AU - Patel, Kevin R

AU - Singam, Vivek

AU - Kantor, Robert

AU - Hsu, Derek Y

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms.OBJECTIVE: We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted.RESULTS: PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82).CONCLUSIONS: PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.

AB - BACKGROUND: Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms.OBJECTIVE: We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD. A prospective dermatology-practice based study of 458 AD patients (age 18-97 years) was conducted.RESULTS: PHQ9 strongly correlated with Dermatology Life Quality Index, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Disturbance and Sleep-Related Impairment, and PROMIS Itch Questionnaire Mood and Sleep (PIQ-MS), and moderately correlated with Patient-Oriented Eczema Measure, Numeric Rating Scale (NRS) average-itch, NRS-sleep, Eczema Area and Severity Index, Scoring AD and Rajka-Langeland scores. PHQ2 had significantly weaker correlations than PHQ9 with PROMIS SD, SRI and PIQ-MS, but similar correlations with other outcomes. PHQ9 and PHQ2 had good discriminant validity. Changes from baseline in PHQ9 and PHQ2 were poorly or weakly correlated with changes of the other outcome measures. There was no differential item functioning of PHQ items. PHQ9 showed good reliability (intraclass correlation coefficient range: 0.80-0.87). PHQ2 had slightly lower reliability (0.76-0.82).CONCLUSIONS: PHQ9 and PHQ2 had similar measurement properties, but PHQ2 was more feasible to assess depressive symptoms in AD.

KW - Atopic Dermatitis

KW - depression

KW - Patient Health Questionnaire-9 (PHQ9)

KW - PHQ2

KW - dermatology-practice based study

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U2 - 10.1097/DER.0000000000000653

DO - 10.1097/DER.0000000000000653

M3 - Article

C2 - 33273219

VL - 32

SP - 225

EP - 231

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 4

ER -

Measurement Properties of Patient Health Questionnaire 9 and Patient Health Questionnaire 2 in Adult Patients With Atopic Dermatitis

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