Mesenchymal stromal cell therapy in haematology: from laboratory to clinic and back again.

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There is currently major interest to use mesenchymal stromal cells (MSC) for a very diverse of therapeutic applications. This stems mainly from the immunosuppressive qualities and differentiation capacity of these cells. In this review we will focus on cell therapy applications for MSC in haematology. In this domain MSC are used for the treatment or prevention of graft versus host disease, support of haematopoiesis or repair of tissue toxicities after haematopoietic cell transplantation. We critically review the accumulating clinical data and elaborate on complications that might arise from treatment with MSC. In addition we assume that the real clinical benefit of using MSC for this purposes, can only be estimated by a better understanding of the influence of in-vitro expansion on the biological properties of these cells as well as by more harmonization of the currently used expansion protocols.
Original languageEnglish
Article number25923433
Pages (from-to)1713-1729
Number of pages17
JournalStem Cells and Development
Issue number15
Early online dateAug 2015
Publication statusPublished - 1 Aug 2015


  • Mesenchymal stem cells
  • Therapy
  • hematology

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