Meta-omics in Inflammatory Bowel Disease Research: Applications, Challenges, and Guidelines

Mireia Valles-Colomer, Youssef El Darzi, Sara Manuel Araujo Vieira Da Silva, Gwen Falony, Jeroen Raes, Marie Joossens

Research output: Contribution to journalScientific reviewpeer-review

32 Citations (Scopus)


Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.
Original languageEnglish
Pages (from-to)735-746
Number of pages12
JournalJ Crohns Colitis
Issue number6
Publication statusPublished - 2016


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