Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling

Sylvie Remy, Eva Govarts, Britt Wens, Patrick De Boever, Elly Den Hond, Kim Croes, Isabelle Sioen, Willy Baeyens, Nicolas van Larebeke, Janna Koppe, Adrian Covaci, Thomas Schettgen, Vera Nelen, Juliette Legler, Greet Schoeters

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Early life exposure to endocrine disrupting chemicals (EDCs) has been frequently associated with impaired perinatal growth, an important risk factor for later onset of metabolic disorders. We analyzed whether the cord blood transcriptome showed early indications of alterations in metabolic processes in 195 human samples in relation to cord blood levels of dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl-153 (PCB-153), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS). Overall, 39 metabolically relevant transcription factors were significantly enriched (31 by p,p'-DDE, 10 by PCB-153, 8 by PFOA, and 2 by PFOS). These included the glucocorticoid receptor (p,p'-DDE and PCB-153) and the progesterone receptor (PFOA and PFOS). The 'insulin receptor signaling', 'acute phase response signaling', 'Interleukin(IL)-6 signaling', and 'prolactin signaling' pathways were significantly enriched in relation to p,p'-DDE. Transcriptional changes at birth suggest a role for specific metabolic targets as a link between prenatal EDC exposure and metabolic disorders later in life.

Original languageEnglish
Pages (from-to)307-320
Number of pages14
JournalReproductive Toxicology
Volume65
DOIs
Publication statusPublished - 31 Aug 2016

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