Projects per year
Abstract
Early life exposure to endocrine disrupting chemicals (EDCs) has been frequently associated with impaired perinatal growth, an important risk factor for later onset of metabolic disorders. We analyzed whether the cord blood transcriptome showed early indications of alterations in metabolic processes in 195 human samples in relation to cord blood levels of dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl-153 (PCB-153), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS). Overall, 39 metabolically relevant transcription factors were significantly enriched (31 by p,p'-DDE, 10 by PCB-153, 8 by PFOA, and 2 by PFOS). These included the glucocorticoid receptor (p,p'-DDE and PCB-153) and the progesterone receptor (PFOA and PFOS). The 'insulin receptor signaling', 'acute phase response signaling', 'Interleukin(IL)-6 signaling', and 'prolactin signaling' pathways were significantly enriched in relation to p,p'-DDE. Transcriptional changes at birth suggest a role for specific metabolic targets as a link between prenatal EDC exposure and metabolic disorders later in life.
Original language | English |
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Pages (from-to) | 307-320 |
Number of pages | 14 |
Journal | Reproductive Toxicology |
Volume | 65 |
DOIs | |
Publication status | Published - 31 Aug 2016 |
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Dive into the research topics of 'Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling'. Together they form a unique fingerprint.Projects
- 3 Finished
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SRP2: Strategic Research Programme: Tracing and Modelling of Past & Present Global Changes
Claeys, P., Elskens, M., Huybrechts, P., Gao, Y., Kervyn De Meerendre, M., Claeys, P., Baeyens, W. & Dehairs, F.
1/11/12 → 31/10/24
Project: Fundamental
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VLW128: Policy Research Centre (PRC) Environment and Health (3rd Generation 2012-2015)
Croes, K., De Craemer, S., Baeyens, W. & Goeyens, K.
1/01/12 → 31/12/15
Project: Policy Based
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VLL37: Steunpunt voor beleidsrelevant onderzoek : Milieu en gezondheid
1/01/07 → 31/12/11
Project: Fundamental