Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

Patrick De Baetselier; Geert Raes; Steve Schoonooghe; Jens De Vos; Tony Lahoutte; Nick Devoogdt; Sophie Hernot; Gezim Bala; Simon Tierens

Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

Patrick De Baetselier (Inventor), Geert Raes (Inventor), Steve Schoonooghe (Inventor), Jens De Vos (Inventor), Tony Lahoutte (Inventor), Nick Devoogdt (Inventor), Sophie Hernot (Inventor), Gezim Bala (Inventor), Simon Tierens (Inventor)

Research output: Patent

Abstract

The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.

Original language	English
Patent number	US9617339
Publication status	Published - 2017

Cite this

De Baetselier, Patrick (Inventor) ; Raes, Geert (Inventor) ; Schoonooghe, Steve (Inventor) ; De Vos, Jens (Inventor) ; Lahoutte, Tony (Inventor) ; Devoogdt, Nick (Inventor) ; Hernot, Sophie (Inventor) ; Bala, Gezim (Inventor) ; Tierens, Simon (Inventor). / Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain. Patent No.: US9617339.

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title = "Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain",

abstract = "The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.",

author = "{De Baetselier}, Patrick and Geert Raes and Steve Schoonooghe and {De Vos}, Jens and Tony Lahoutte and Nick Devoogdt and Sophie Hernot and Gezim Bala and Simon Tierens",

year = "2017",

language = "English",

type = "Patent",

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Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain. / De Baetselier, Patrick (Inventor); Raes, Geert (Inventor); Schoonooghe, Steve (Inventor); De Vos, Jens (Inventor); Lahoutte, Tony (Inventor); Devoogdt, Nick (Inventor); Hernot, Sophie (Inventor); Bala, Gezim (Inventor); Tierens, Simon (Inventor).

Patent No.: US9617339.

Research output: Patent

TY - PAT

T1 - Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

AU - De Baetselier, Patrick

AU - Raes, Geert

AU - Schoonooghe, Steve

AU - De Vos, Jens

AU - Lahoutte, Tony

AU - Devoogdt, Nick

AU - Hernot, Sophie

AU - Bala, Gezim

AU - Tierens, Simon

PY - 2017

Y1 - 2017

N2 - The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.

AB - The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.

UR - https://worldwide.espacenet.com/patent/search/family/050280417/publication/US2016024213A1?q=US9617339

M3 - Patent

M1 - US9617339

ER -

Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

Abstract

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