Methodological approaches to compile and validate a food composition database for methyl-group carriers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Heleen Van Puyvelde, Vickà Versele, Marlène De Backer, Corinne Casagrande, Geneviève Nicolas, Joanna L. Clasen, Cristina Juliàn, Guri Skeie, Maria-Dolores Chirlaque, Yahya Mahamat-Saleh, Pilar Amiano, Sara Pauwels, Lode Godderis, Marc J. Gunter, Koen Van Herck, Inge Huybrechts

Research output: Contribution to journalArticle

Abstract

A standardised methodology was used to compile and validate a methyl-group carrier database (MGDB) including folate, choline, betaine and methionine, for use in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Compilation was performed by following structured guidelines to match the EPIC dietary intake data to food items from four food composition databases, according to their assigned priority of use. To assess relative validity, calculated dietary folate intakes were compared between the MGDB and the EPIC nutrient database (ENDB), used as the reference database. Folate intakes based on the MGDB and those generated using the ENDB showed good agreement (weighted κ = 0.63) and were strongly correlated (r = 0.81). This MGDB can be used for investigating potential associations between methyl-group carrier intakes and risk or prognosis of cancer and other diseases in the EPIC study population.

Original languageEnglish
Article number127231
JournalFood Chemistry
Volume330
DOIs
Publication statusPublished - 15 Nov 2020

Keywords

  • Keywords Food composition databaseMethyl-group carriersFolateCholineBetaineMethionineComparative study

Fingerprint Dive into the research topics of 'Methodological approaches to compile and validate a food composition database for methyl-group carriers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.'. Together they form a unique fingerprint.

Cite this