MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ

Jan Van Autreve; Bobby Koeleman; Erik Quartier; Folefac Aminkeng; Bart Van Der Auwera; Ilse Weets; Frans Gorus

MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ

Jan Van Autreve, Bobby Koeleman, Erik Quartier, Folefac Aminkeng, Bart Van Der Auwera, Ilse Weets, Frans Gorus

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICAS was significantly increased in the T1D patient group (18%) compared with the control population (12%, OR = 1.6, pc <10-3), whereas MICA9 was decreased (11% versus 16%, OR = 0.7, pc <0.01). A p value

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Human Immunology
Volume	67
Publication status	Published - 2006

Bibliographical note

Human Immunology 67:94-101, 2006

Keywords

MICA
HLA
risk
type 1 diabetes

Lecture: Functional genetics of type 1 diabetes
Bart Van Der Auwera (Member)
26 Nov 2004
Activity: Other › Types of External academic engagement - Hosting an academic visitor

Cite this

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title = "MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ",

abstract = "To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICAS was significantly increased in the T1D patient group (18%) compared with the control population (12%, OR = 1.6, pc <10-3), whereas MICA9 was decreased (11% versus 16%, OR = 0.7, pc <0.01). A p value",

keywords = "MICA, HLA, risk, type 1 diabetes",

author = "{Van Autreve}, Jan and Bobby Koeleman and Erik Quartier and Folefac Aminkeng and {Van Der Auwera}, Bart and Ilse Weets and Frans Gorus",

note = "Human Immunology 67:94-101, 2006",

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T1 - MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ

AU - Van Autreve, Jan

AU - Koeleman, Bobby

AU - Quartier, Erik

AU - Aminkeng, Folefac

AU - Van Der Auwera, Bart

AU - Weets, Ilse

AU - Gorus, Frans

N1 - Human Immunology 67:94-101, 2006

PY - 2006

Y1 - 2006

N2 - To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICAS was significantly increased in the T1D patient group (18%) compared with the control population (12%, OR = 1.6, pc <10-3), whereas MICA9 was decreased (11% versus 16%, OR = 0.7, pc <0.01). A p value

AB - To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICAS was significantly increased in the T1D patient group (18%) compared with the control population (12%, OR = 1.6, pc <10-3), whereas MICA9 was decreased (11% versus 16%, OR = 0.7, pc <0.01). A p value

KW - MICA

KW - HLA

KW - risk

KW - type 1 diabetes

M3 - Article

VL - 67

SP - 94

EP - 101

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

ER -

MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ

Abstract

Bibliographical note

Keywords

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Activities

Lecture: Functional genetics of type 1 diabetes

Cite this