Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

Afroditi Mertzanidou; Leeanda Wilton; Jiqiu Cheng; Claudia Spits; E. Vanneste; Yves Moreau; J.r. Vermeesch; Karen Sermon

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

Afroditi Mertzanidou, Leeanda Wilton, Jiqiu Cheng, Claudia Spits, E. Vanneste, Yves Moreau, J.r. Vermeesch, Karen Sermon

Research output: Contribution to journal › Article › peer-review

165 Citations (Scopus)

Abstract

STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

Original language	English
Pages (from-to)	256-264
Number of pages	9
Journal	Human Reproduction
Volume	28
Publication status	Published - 28 Jan 2013

Keywords

human preimplantation embryo
chromosomal abnormality

IWT330: Molecular karyotyping
Mertzanidou, A., Sermon, K. & Liebaers, I.
1/10/07 → 30/09/11
Project: Fundamental

Cite this

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abstract = "STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age",

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Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos. / Mertzanidou, Afroditi; Wilton, Leeanda; Cheng, Jiqiu; Spits, Claudia; Vanneste, E.; Moreau, Yves; Vermeesch, J.r.; Sermon, Karen.

In: Human Reproduction, Vol. 28, 28.01.2013, p. 256-264.

Research output: Contribution to journal › Article › peer-review

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AU - Mertzanidou, Afroditi

AU - Wilton, Leeanda

AU - Cheng, Jiqiu

AU - Spits, Claudia

AU - Vanneste, E.

AU - Moreau, Yves

AU - Vermeesch, J.r.

AU - Sermon, Karen

PY - 2013/1/28

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N2 - STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

AB - STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

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KW - chromosomal abnormality

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Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

Abstract

Keywords

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Projects

IWT330: Molecular karyotyping

Cite this