Migration behavior of low-density particles in lab-on-a-disc devices: Effect of walls

Vyacheslav R. Misko, Agata Kryj, Aude Muriel Tamandjo Ngansop, Sogol Yazdani, Matthieu Briet, Namanya Basinda, Humphrey D. Mazigo, Wim De Malsche

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the lateral walls of a Lab-On-a-Disc device on the dynamics of a model system of particles with a density lower than that of the solvent (modelling parasites eggs) is analyzed theoretically and experimentally. In the absence of lateral walls, a particle always moves in the direction of the centrifugal force, while its trajectory is deflected in the tangential direction by the inertial Coriolis and Euler forces. Lateral walls, depending on the angle forming with the radial direction, can guide the particle either in the same or in the opposite direction to the centrifugal force, thus resulting in unusual particle trajectories including zig-zag or backwards particle motion. The effect is pronounced in the case of short operation times when the acceleration of the angular rotation, and thus the Euler force, is considerable. The predicted unusual motion is demonstrated by numerically solving the equation of motion in the presence of lateral walls and verified in the experiment with particles of density lower than that of the solvent. Our analysis is useful for design and operational considerations of Lab-On-a-Disc devices aiming for or involving (bio)particle handling.

Original languageEnglish
Article number1032
JournalMicromachines
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Diagnostic microfluidic device
  • Extreme point-of-care
  • Parasite egg identification and quantification
  • Particle separation

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