Mitochondria as target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods

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Abstract

One of the major mechanisms of drug-induced liver injury includes mitochondrial perturbation and dysfunction. This is not a surprise, given that mitochondria are essential organelles in most cells, which are responsible for energy homeostasis and the regulation of cellular metabolism. Drug-induced mitochondrial dysfunction can be influenced by various factors and conditions, such as genetic predisposition, the presence of metabolic disorders and obesity, viral infections, as well as drugs. Despite the fact that many methods have been developed for studying mitochondrial function, there is still a need for advanced and integrative models and approaches more closely resembling liver physiology, which would take into account predisposing factors. This could reduce the costs of drug development by the early prediction of potential mitochondrial toxicity during pre-clinical tests and, especially, prevent serious complications observed in clinical settings.
Original languageEnglish
Article number3315
Number of pages39
JournalInternational Journal of Molecular Sciences
Volume23
Issue number6
DOIs
Publication statusPublished - 18 Mar 2022

Bibliographical note

Funding Information:
This work was financially supported by the Marie Skłodowska-Curie COFUND Action (Grant Agreement 101034352 “imπACT”), the Future and Emerging Technologies (Grant Agreement 858014 “PANACHE”) and the Societal Challenges (Grant Agreement 963845 “ONTOX”) sections of the European Horizon2020 framework program, the US Alternatives Research and Development Foundation (Grant 2021), the Research Foundation Flanders (Grant Agreement G070422N), the Methusalem program of the Flemish government (Grant 2020), and the Scientific Fund Willy Gepts (Grant 2021).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

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