Modulation of connexin signalling by bacterial pathogens and their toxins.

Liesbeth Ceelen, Freddy Haesebrouck, Tamara Vanhaecke, Vera Rogiers, Mathieu Vinken

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Inherent to their pivotal tasks in the maintenance of cellular homeostasis, gap junctions, connexin hemichannels and pannexin hemichannels are frequently involved during dysregulation of this critical balance. The present paper specifically focuses on their roles in bacterial infection and disease. In particular, the reported biological outcome of Escherichia coli, Shigella flexneri, Yersinia enterocolitica, Helicobacter pylori, Bordetella pertussis, Aggregatibacter actinomycetemcomitans, Pseudomonas aeruginosa, Citrobacter rodentium, Clostridium species, Streptococcus pneumoniae and Staphylococcus aureus and their toxic products on connexin- and pannexin-related signalling in host cells is reviewed. Particular attention is paid to the molecular mechanisms that underlie these effects as well as to the actual biological relevance of these findings.
Original languageEnglish
Pages (from-to)3047-3064
Number of pages18
JournalCellular and Molecular Life Sciences
Publication statusPublished - 1 Sep 2011


  • connexin
  • bacteria
  • toxin
  • pannexin


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